This active substance in coffee - no, it's not caffeine - lowers your fat percentage
Supplementation with chlorogenic acid, a phytochemical that we ingest in large quantities every day through regular foods such as vegetables and coffee, reduces fat mass and improves cholesterol balance.
Researchers from the R&D department of the Indian company Vidya Herbs divided 71 healthy but somewhat obese subjects with a BMI of 25-30 into 2 groups. For 12 weeks, one group took a placebo daily, while the subjects in the other group took 500 milligrams of Green Coffee Bean extract daily. During the trial, the study participants did not change their lifestyle.
The extract that the researchers used was a product of Vidya Herbs itself. It's called CGA-7. So we are talking about a sponsored study.
CGA-7 consists of 50 percent chlorogenic acid. Chlorogenic acid is a catchall term for a group of dozens of compounds, of which 7 are present in CGA-7.
According to an analysis by Vidya Herbs, the 3 main chlorogenic acid variants in CGA-7 are 3-O-caffeoylquinic acid [3-CQA], 4-O-caffeoylquinic acid [4-CQA] and 5-O-caffeoylquinic acid [5-CQA].
Mechanism of action
Chlorogenic acid probably activates the AMPK molecule in cells. As a result, the liver converts less glucose into glycogen (by which mechanism, long story short, supplementation with chlorogenic acid can reduce the concentration of triglycerides in the blood).
At the same time, the activity and perhaps also the production of the glucose transporter GLUT4 increases in the muscle cells. As a result, the muscles absorb more glucose. Chlorogenic acid therefore not only has a positive effect on the concentration of triglycerides in the blood, but also on the glucose and insulin balance.
The supplement industry goes one step further and claims that supplementation with chlorogenic acid reduces fat mass. According to meta-data, this claim may well be true.
In the 12 weeks that the experiment lasted, the subjects who received CGA-7 lost an average of 2.6 kilograms of their body weight. Their waist size decreased by 1.5 cm.
Click on the tables below for a larger version.
Less body fat
The decrease in body weight was mainly due to fat mass. The subjects who used CGA-7 lost an average of 2 kilograms of body fat.
Supplementation with CGA-7 improved cholesterol balance. In particular, the concentration of triglycerides decreased.
A few days ago we wrote about the positive effects of edible mushroom supplementation on insulin action and body weight. Could chlorogenic acid enhance those effects?
The active ingredients in those edible mushrooms are polysaccharides that interact with GLUT4. Chlorogenic acid also works via GLUT4, but possibly in a different way. Perhaps there is synergy.
More coming soon.
SAGE Open Med. 2021 Mar 19;9:20503121211002590.
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