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What happens to bodybuilders if they take 3 grams of arginine and half a gram of vitamin C daily?

If bodybuilders take 3 grams of L-arginine and 500 milligrams of vitamin C daily for a month and a half, they gain muscle mass and lose body fat at the same time. Their testosterone levels rise significantly - and moreover, the bodybuilders become fitter.


What happens to bodybuilders if they take 3 grams of arginine and half a gram of vitamin C daily?


Study
In July 2026, researchers from Urmia University of Medical Sciences in Iran published a human study in the Journal of Diabetes and Metabolic Disorders involving 50 recreational bodybuilders.

The bodybuilders were male and in their mid-twenties. They trained three times a week. Each training session consisted of a 20-minute cardio session and a workout with basic exercises such as the bench press, leg press, lat pulldown, squats, and shoulder press.

The researchers divided their subjects into a placebo group and an experimental group. The bodybuilders in the experimental group took 3 capsules containing 1000 milligrams of L-arginine each, spread throughout the day. In addition, they also took a supplement with half a gram of vitamin C every day.

The supplementation period lasted 45 days.

The researchers chose this combination because they suspected that arginine is primarily effective because it acts as a source of nitric oxide, or NO. Because NO is rapidly broken down by free radicals and because vitamin C neutralizes those free radicals, they hoped that the addition of vitamin C would make arginine a more effective NO donor.


What happens to bodybuilders if they take 3 grams of arginine and half a gram of vitamin C daily?


Results
The two most notable effects of supplementation were an increase in maximal oxygen uptake and testosterone levels. In the supplementation group, VO2max and testosterone levels increased by 10 and 26 percent, respectively.

Additionally, the researchers observed a modest but noticeable improvement in body composition in the supplementation group. Fat mass decreased by 7 ounces, while lean mass increased by half a kilo.

Click on the table below for a larger version.


What happens to bodybuilders if they take 3 grams of arginine and half a gram of vitamin C daily?


Conclusion
"These findings suggest that this supplemental strategy can be an effective and safe nutritional intervention to support training adaptation in resistance-trained athletes", write the Iranians.

"Future research should focus on elucidating the mechanisms behind the testosterone-boosting effect, exploring optimal dosing strategies, and investigating the long-term efficacy of this combination in broader athletic cohorts."

More:
In these doses, arginine supplements improve sports performance 22.05.2023
Why NO-boosters with a modest amount of arginine and citrulline can still be effective 11.05.2023
Just over two grams of arginine-citrulline combi enough to make athletes faster and fitter 29.10.2019
Modest dose of two grams of L-arginine per day makes athletes even fitter 21.02.2018
Better NO boosters contain a combination of L-arginine and L-citrulline 11.02.2015

Archives:
Nutrition & Strength Training
Nitric Ocide [NO]
Amino Acids
L-Arginine
Vitamin C
Vitamins


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