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28.05.2023


Low vitamin D levels induce acne

Low vitamin D levels can increase the risk of acne. And, just as you might expect, normalizing low vitamin D levels through supplementation can make acne less severe.


Low vitamin D levels can increase the risk of acne. And, just as you might expect, normalizing low vitamin D levels through supplementation can make acne less severe.


Epidemiology
South Korean dermatologists affiliated with Chungnam National University published a small epidemiological study and a small intervention study in PLoS One in 2016, in which they studied whether an adequate vitamin D status reduced the risk of acne.

The researchers got their money from the South Korean government, not from a supplement manufacturer.

In the epidemiological study, the researchers measured the vitamin D levels of 80 Koreans with acne with the vitamin D levels of 80 Koreans without acne. They found that a vitamin deficiency was significantly more common in the first group than in the second.

Click on the table for a larger version.


Low vitamin D levels can increase the risk of acne. And, just as you might expect, normalizing low vitamin D levels through supplementation can make acne less severe.


Low vitamin D levels can increase the risk of acne. And, just as you might expect, normalizing low vitamin D levels through supplementation can make acne less severe.


Low vitamin D levels can increase the risk of acne. And, just as you might expect, normalizing low vitamin D levels through supplementation can make acne less severe.


Intervention study
The Koreans divided 39 subjects with acne into 2 groups. All subjects had low vitamin D levels. For 8 weeks, the subjects in one group took a placebo every day, while the subjects in the other group took a supplement containing 1000 IU of vitamin D3 every day.

Although the supplement was dosed too low to bring the vitamin D level to a sufficient level over a period of 2 months [first figure below], the researchers saw that acne decreased in the vitamin D group [second figure below - click on it for a larger version]. However, that decrease was not statistically significant.

However, if the researchers looked exclusively at inflammatory acne, there was a statistically significant decrease in the acne group.


Low vitamin D levels can increase the risk of acne. And, just as you might expect, normalizing low vitamin D levels through supplementation can make acne less severe.


Low vitamin D levels can increase the risk of acne. And, just as you might expect, normalizing low vitamin D levels through supplementation can make acne less severe.


Mechanism
The Koreans suspect that vitamin D counteracts inflammation in skin tissue. They base this idea on in vitro research in which vitamin D reduces the activity of inflammatory factors such as interleukin-6 and interleukin-8 and matrix metalloproteinase-9 [MMP-9] in skin cells that produce sebum. [Indian J Dermatol. 2013 Jul;58(4):327.]

The researchers also point to research in which vitamin D increases the production of an antimicrobial peptide such as LL-37 in sebum-producing cells. [Arch Dermatol Res. 2012 Oct;304(8):627-32.]

Source:
PLoS One. 2016 Aug 25;11(8):e0161162.

More:
30 milligrams of elemental zinc helps against acne 15.05.2023
EPA, DHA, and GLA fight acne 27.06.2020
Vitamin B5 beats acne 03.01.2016

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