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19.05.2024

Just like pinitol, piceatannol may rejuvenate the skin - but in a slightly different way

The day before yesterday we wrote about the positive effect of pinitol on the skin. Eleven years earlier we discussed another study in which piceatannol, a completely different type of compound than pinitol, does much the same thing. And today we came across a Japanese in vitro study with the same outcome. Would pinitol and piceatannol enhance each other's effect on the skin?

Study
In 2013, an in vitro study was published in Biological and Pharmaceutical Bulletin, which came from the Japanese company Morinaga. Morinaga produces food products.

In this study, the Japanese irradiated skin cells with UV light and then looked at whether piceatannol modulated the response of the cells. Piceatannol is a metabolite of resveratrol that is produced in the body, but is also present in herbs, fruits and vegetables. Relatively large concentrations are present in the seeds of passion fruits.

Results
Like pinitol, piceatannol reduced the activity of free oxygen radicals in the irradiated skin cells. And like pinitol, piceatannol reduced the activity of the collagen-degrading enzyme MMP-1.

Mechanism
Hoe piceatannol huicellen beschermt tegen UV-licht - en misschien ook indirect de veroudering van de huid vertraagt - zie je in de figuur hierboven. Piceatannol verhoogt de concentratie van de endogene antioxidant glutathion [GSH].

Speculation
Pinitol probably works in a different way. Compounds such as inositol or pinitol make signaling molecules in the cell function better.

Pinitol and piceatannol achieve the same effect in skin cells, but in a different way. In theory, these two substances are ideally suited to be combined in a skinceutical formula.

More coming soon.

Source:
Biol Pharm Bull. 2013;36(5):845-9.

More:
Pinitol protects the skin against UV light (and possibly slows down skin aging) 17.05.2024
Pinitol stimulates collagen production 17.11.2013

Archives:
Resveratrol & piceatannol
Cosmeceuticals

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