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16.12.2023

Collagen hydrolyzate as a skin rejuvenator | The most effective dose is surprisingly low

Hydrolyzed collagen is a proven cosmeceutical. When it comes to products that keep skin young and healthy, collagen is perhaps the most thoroughly studied supplement. Moreover, according to a Japanese animal study, the effective dose is surprisingly low.

Study
In 2016, Japanese protein chemists at Tokyo University of Agriculture and Technology published an animal study in Bioscience, Biotechnology, and Biochemistry in which they exposed hairless mice to increasingly powerful ultraviolet light for a month. Some of the test animals were also given a relatively low, a high and a particularly high dose of collagen hydrolyzate via their drinking water.

Mice in a control group were not irradiated but also did not receive collagen hydrolyzate. Animals in yet another control group were irradiated, but also did not receive collagen hydrolyzate.

Exposure to high doses of ultraviolet light accelerates skin aging. Substances that keep the skin healthy during exposure to powerful ultraviolet light are also likely to protect against skin aging.

Results
When the month was over, the researchers determined how much water was present in the outer layer [corneum] of the mice's skin. Skin affected by ultraviolet light becomes drier. As you can see below, all doses of collagen hydrolyzate prevented skin dehydration.

Damaged skin cannot properly prevent the loss of water from the body. When the skin is damaged, transepidermal water loss [TEWL] increases. The figure above shows that collagen hydrolyzate in the most modest doses protected against this - and the higher doses did not.

According to the Japanese, the human equivalent of the most effective dose of collagen hydrolyzate, for someone weighing 60 kilos, is 1.2 grams per day.

Source:
Biosci Biotechnol Biochem. 2016;80(2):356-9.

More:
This combination of astaxanthin and collagen keeps your skin young 17.11.2020
How collagen keeps the wrinkles at bay 13.03.2012
Animal study: hydrolysed collagen keeps skin young 05.03.2012

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