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16.03.2022

How white button mushrooms might take the sting out of diabetes and delay aging

The readers of this website are well aware that advanced glycation end products [AGEs] are very, very bad. The more glucose circulating in your body - for example because you are in a preliminary stage of type 2 diabetes - the more AGEs are formed, the more tissues are damaged and the faster the aging process. Fortunately, there is a food that inhibits the formation of AGEs.
The ordinary white button mushroom.

Study
American food scientists gave 37 test subjects, all of whom were in the early stages of type 2 diabetes, a dish containing 100 grams of mushrooms every day for 16 weeks.

There was no control group.

Just before and just after these 16 weeks, the researchers analyzed the blood of the test subjects. A month later, the researchers did it again.

Results
After they had eaten mushrooms for 16 weeks, the subjects' blood contained considerably more of the longevity compound ergothioneine. In addition, the blood's ability to neutralize potentially damaging free oxygen radicals was increased [ORAC].

The addition of the mushrooms to the diet also resulted in an increase in the 'good fat cell hormone' adiponectin. Adiponectin allows cells to absorb more glucose and inhibits inflammation.

These shifts may explain why the concentrations of carboxymethyllysine [CML] and methylglyoxal [MG] in the subjects' blood had decreased. Both substances are AGEs. AGEs are formed when glucose reacts with proteins. AGEs can damage all kinds of tissues and accelerate aging.

AGEs
You can read more about AGEs [here], [here] and [here]. This website has previously written about the anti-AGEing effect of a diet high in edible mushrooms.

Sponsor
The research was funded by the US Mushroom Council [mushroomcouncil.com] and the Australian Mushroom Growers Council [australianmushroomgrowers.com.au]. Both are organizations of and for the mushroom sector.

Conclusion
"Overall these preliminary findings from the addition of one serving of mushrooms to a variety of different dietary intake patterns suggest potential anti-inflammatory and antioxidant health benefits that can occur with frequent consumption over time in adults predisposed to type-2 diabetes", write the researchers.

"Well-controlled studies are needed to confirm these findings and identify the specific mushroom components beneficial to health."

Source:
Plant Foods Hum Nutr. 2016 Sep;71(3):245-51.

More:
Eat mushrooms and live (a bit) longer 06.01.2022
Meta-study confirms protective effect of edible mushrooms against cancer 27.07.2021
Edible mushrooms keep skin young 29.01.2020

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