This analogue of rutin extends life by 10 percent
A rutin analogue with increased bioavailability extends the lifespan of laboratory animals by 10 percent, concludes a Chinese study published in the British Journal of Pharmacology. The human equivalent of the daily dose used in this study fits into a capsule.
From their 32nd week of life, mice were given lifelong drinking water in which researchers at Capital Medical University in Beijing had dissolved sodium rutinate. If the mice had been humans, they would have received about 160-240 milligrams of sodium rutinate daily.
Sodium rutinate is produced by successively treating rutin - probably the most abundant polyphenol in the human diet - with caustic soda and hydrochloric acid. This treatment increases the solubility of rutin by more than a factor of 200. [Sci Adv. 2019 Feb 27;5(2):eaau6328.]
Rutin sodium, as the Chinese call the rutin analogue they use, extended the mean and maximum lifespan of the mice by 10 percent.
When the mice were middle-aged, they ran faster if they had been given rutin sodium. Moreover, after the researchers had placed them on a rotating axis, they tumbled down less quickly. This indicates that rutin sodium kept the mice physically and motor fit.
The mice that had been given rutin sodium also looked younger. Their fur was in better condition than that of the animals who had not been given rutin sodium. This also points to better health in aging mice.
As organisms age, the concentration of beta-galactose in their cells increases. Beta-galactose is a marker of cell aging at the molecular level. The researchers found less beta-galactose in the cells of older mice that had been given rutin sodium.
"Our study strongly implicates that sodium rutin is a promising drug candidate for targeting aging," the researchers write.
"We suggest that sodium rutin could be used in anti-aging therapy and for the treatment of aging-associated diseases."
Br J Pharmacol. 2022 May;179(9):1825-38.
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