Definition: "An ergogenic aid is any substance or phenomenon that enhances performance "
Hesperetin, the cellular rejuvenator from citrus fruits
Hesperetin, a flavonoid in citrus fruits, may extend life. According to a Taiwanese animal study, hesperetin rejuvenates the mitochondria. By this mechanism, hesperetin stops the aging of muscles, body composition and glucose metabolism.
In the animal study we're going to bore you with today, researchers gave mice hesperetin in its bare form. Scientists have mainly focused on glycated analogues of hesperetin. We get these in quantities of several tens of milligrams through, among other things, citrus fruits. You can probably use these analogues, together with caffeine [Phytother Res. 2015 Feb;29(2):310-6.] or synephrine, as a weight loss supplement.
The Taiwanese gave a group of older lab mice a hefty dose of hesperetin via their food for several months. If the mice had been adults weighing 70 kilograms, they would have consumed 700 milligrams of hesperetin daily.
Mice in the two control groups were fed chow without additives. In one control group, the mice were the same age as the animals in the experimental group. In the other control group mice were still young.
The researchers discovered that hesperetin slowed the aging of the heart muscle and maintained insulin sensitivity. Hesperetin supplementation also reduced the breakdown of muscle tissue and inhibited the increase of adipose tissue.
The mice also consumed more energy as a result of supplementation.
That is what the figures below tell.
Mitochondria are cellular power plants. They convert nutrients into energy. According to a large group of researchers, aging is at least partly the result of increasingly poorer functioning mitochondria.
"Additionally, it has no detectable in vivo toxicity after long-term oral administration for 6-7 months in mice, specifically when supplemented in food at a dose of 100 mg/kg/day, which has a human equivalent dose of 491 mg/60 kg/day."
"Accordingly, it will be of great interest to develop hesperetin as a medicinally or nutritionally functional food for preventive purposes related to extending healthy lifespan and/or therapeutic purpose related to treating age related diseases."