Obese with a fatty liver? This dose of myo-inositol makes you healthier

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27.02.2023

Supplementation with 4 grams of myo-inositol per day may make obese people healthier. Their cholesterol improves, their insulin sensitivity increases, blood pressure decreases and body weight decreases. In addition, their liver will function better.

Inositol

Vegetables such as beans, eggplant and Brussels sprouts are good dietary sources of inositol. Inositol is a group of compounds that physiologists sometimes refer to as 'pseudovitamins'. Myo-inositol is one of these pseudovitamins.

The exact biological function of inositol in the body is not yet fully known, but we do know from basic research that cells attach inositol to phosphate groups. These complexes then act as second messengers. This means that they transmit the signals of a variety of hormones, growth factors and neurotransmitter to the information molecules in the cell nucleus. By increasing inositol intake, cells become more responsive to hormones like testosterone, nor-epinephrine and insuline.

Study

Researchers at Tabriz University of Medical Sciences in Iran conducted an eight-week experiment with 48 obese subjects aged 18-55. All subjects had a mild degree of fatty liver disease or, as the researchers prefer to call it, non-alcoholic fatty liver disease.

Half of the subjects took 2 grams of myo-inositol twice a day. They were given sachets of powder that they had to dissolve in a glass of water. They drank that during lunch or dinner. So in total they consumed 4 grams of myo-inositol per day.

The subjects in the placebo group did the same. Their sachets did not contain myo-inositol, but maltodextrin.

Results
Supplementation with myo-inositol reduced the body weight of the subjects by just under 5 kilograms. The subjects in the placebo group lost just over 3 kilograms.

Systolic blood pressure decreased by 4 points in the experimental group, while it did not change significantly in the placebo group. Diastolic blood pressure decreased by 9 points on supplementation, while diastole in the placebo group did not change significantly.

Supplementation improved cholesterol and insulin balance. In the experimental group, triglycerides, LDL and HDL and insulin sensitivity improved.

At the same time, some liver enzyme values improved in the supplementation group. This suggests that myo-inositol supplementation helps the liver function better.

Conclusion
"Myo-inositol supplementation at a dose of 4 g/day for 8 weeks significantly improves not only insulin resistance and lipid profile but also liver function in non-alcoholic fatty liver disease", resume the Iranians.

"Because of the limited number of randomized controlled trial in humans, further clinical trials with larger sample sizes, longer duration, different myo-inositol doses, and other inositol derivatives are recommended."

Source:
Front Nutr. 2023 Feb 7;10:1092544.

More:
Two capsules of D-chiro-inositol per day: more testosterone, less estradiol, less body fat and greater insulin sensitivity 16.11.2021

Archives:
Insulin & Glucose Metabolism
Cardiovascular Health
Inositol
Liver



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