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31.05.2023

EPA reduces eczema

Supplementation with a hefty dose of EPA reduces eczema. Researchers at Shahid Beheshti University of Medical Sciences in Iran discovered this when they gave 24 children with eczema a supplement containing 500 milligrams of EPA every day for a month.

Study
Bahador Mirrahimi experimented with 48 children up to the age of 18, all of whom suffered from atopic dermatitis and were treated with drugs such as hydrocortisone acetate gels. The parents of the children were advised to put sea food on the table 1-3 times a week.

Mirrahimi divided the children into 2 groups. The narrow group took a placebo daily for a month, the other group took 2 capsules, each containing 250 milligrams of EPA, spread over the day. In total, the children in this group consumed 500 milligrams of EPA per day.

Results
The researchers gave the severity of the eczema a score [SCORAD] based on the area of the affected skin, the intensity of the eczema and the symptoms reported by the children. The scores decreased in both groups, but this decrease was significantly greater in the EPA group.

Of all children who used corticosteroids, 64 percent in the placebo group were still using corticosteroids after 4 weeks. In the experimental group this was 33 percent.

Mechanism
Mirrahimi suspects that EPA displaces the omega-6 fatty acids. Normally, enzymes convert omega-6 fatty acids into inflammatory factors. When these enzymes convert EPA, compounds are created that do not provoke inflammation.

Source:
J Pediatr Pharmacol Ther. 2023;28(1):29-35.

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