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The B in vitamin B1 stands for 'bone'
If people over 40 take a supplement with 56 milligrams of vitamin B1 every day, their bones might become a little stronger. According to Japanese researchers, the supplement reduces the activity of the bone-degrading osteoclasts in bone tissue.
Study
Japanese researchers, affiliated with Kanazawa University, gave 42 people over the age of forty two pills of vitamin B1 every day for a month. The Japanese used a product from Otsuka Pharmaceutical that provided 28 milligrams of vitamin B1 per pill. The subjects therefore consumed 56 milligrams of vitamin B1 daily.
That is considerably more than healthy people according to the sloppy milligrams that adults need daily according to the guidelines. There is no upper limit for vitamin B1 intake.
There was no control group.
Before and after the supplementation, the researchers measured the concentration of a few biomarkers for bone formation and breakdown in the subjects' blood.
Results
The concentration of N-terminal propeptide or type I procollagen [P1NP] did not change. P1NP is a protein that is released when bone tissue rejuvenates. More P1NP means more bone tissue production.
The concentration of tartrate-resistant acid phosphatase 5b [TRACP5b] decreased by 11.3 percent. TRACP5b is released when the bone-degrading osteoclasts in bone tissue are more active. More TRACP5 means more bone breakdown.
The decrease in TRACP5b is statistically significant, but the researchers wonder whether it is also clinically significant - read: whether the bones of the test subjects actually become stronger. Follow-up research should provide clarity on this.
Mechanism
In in vitro research, vitamin B1 inhibits the action of the inflammatory factor NF-kappa-B. NF-kappa-B prompts osteoclasts to develop into destroyers of bone tissue.
Conclusion
"The results of the present study may create a hypothesis that vitamin B1 is associated with bone health in humans", the Japanese summarize.
"Further studies are needed to determine the effects and mechanisms underlying the impact of vitamin B1 on bone health and the differences in these effects by individual characteristics."
Source:
J Nutr Sci. 2025 May 8:14:e34.
More:
Vitamin B for stronger bones 02.01.2023
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