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02.12.2022


Supplement with glycine and N-acetylcysteine lowers insulin resistance in type-2 diabetics

Supplementation with GlyNAC, a combination of glycine and N-acetyl cysteine, allows mice to live much longer, we wrote a few months ago. The same supplement makes type 2 diabetics a lot healthier. But oh my gosh, what gigantic doses did American researchers need for that...


Supplement with glycine and N-acetylcysteine lowers insulin resistance in type-2 diabetics


Study
Rajagopal Sekhar, a diabetologist from Baylor College of Medicine in the US, invests a lot of his time and energy in GlyNAC. He publishes extensively on the supplement and holds a number of patents for the medical use of GlyNAC. [patents.justia.com]

In the first months of 2022, Sekhar published a small study in which 10 people with type 2 diabetes used GlyNAC every day for 14 days. GlyNAC consists of equal parts glycine and NAC. The subjects received 1 gram of glycine and 1 gram of NAC per 10 kilograms of body weight daily.


Supplement with glycine and N-acetylcysteine lowers insulin resistance in type-2 diabetics


This dose is quite high. Don't try this at home, folks.

All subjects were treated by a physician. They were given medication, but did not yet use insulin.

Results
Just before and in the final phase of the supplementation period, Sekhar analyzed the subjects' breath. This happened early in the morning, even before the subjects had had breakfast.

Sekhar found that supplementing with GlyNAC increased carbohydrate oxidation by 30 percent.


Supplement with glycine and N-acetylcysteine lowers insulin resistance in type-2 diabetics

Supplement with glycine and N-acetylcysteine lowers insulin resistance in type-2 diabetics


Diabetes implies that cells cannot properly take up glucose, but GlyNAC improved that ability to some extent. This is also apparent from the effect on the insulin resistance of the test subjects in the GlyNAC group. It decreased by 22 percent.

Conclusion
"These results could have important implications for improving health in diabetes, and support the need for a randomized clinical trial to confirm these findings and to understand the impact of GlyNAC supplementation on defects linked to mitochondrial dysfunction in diabetes", writes Sekhar.

Source:
Antioxidants (Basel). 2022 Jan 13;11(1):154.

More:
Animal study | Combination of glycine and NAC extends maximum lifespan by 40 percent 09.03.2022
NAC helps some athletes to speed up 09.11.2010
Combination of selenium and NAC raises testosterone levels 18.01.2009

Archives:
Insulin & Glucose Metabolism
Amino Acids
Glycine


Glycine supplementation extends life span Daily dose of 1500 mg of taurine slows aging AKG cycle makes you up to 8 years younger

Glycine supplementation extends life span
American anti-aging researchers gave mice a hefty dose of glycine throughout their lives, and discovered that it made the animals live longer.

Daily dose of 1500 mg of taurine slows aging
Part of the aging process is due to free oxygen radicals that damage cells and tissues.

AKG cycle makes you up to 8 years younger
A real human study, although conducted without a control group.