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AKG cycle makes you up to 8 years younger
According to in vitro and animal data, AKG is a promising longevity supplement. A real human study, although conducted without a control group, points in the same direction.
Study
The researchers gave 42 subjects one gram of AKG every day for 4-10 months. The researchers used Rejuvant, [rejuvant.com] a product from Ponce de Leon Health. [pdlhealth.com]
Rejuvant contains AKG in the form of a calcium salt.
Ponce de Leon Health releases Rejuvant in two versions. One version is intended for men, and contains vitamin A in addition to calcium-AKG. The other version is intended for women, and contains vitamin D in addition to calcium-AKG.
The researchers determined the effect of AKG supplementation with the TruAge test. [trumelabs.com] This test measures in saliva how many methyl groups are attached to the DNA. The more methyl groups the test finds, the further the aging process has progressed.
Financing
The authors of the study we're currently bugging you with work for the manufacturer of the TruAge test. According to the paper, Ponce de Leon Health did not sponsor the study.
The University of Singapore paid the resesearch.
Results
Before starting the supplementation, the researchers determined the difference between the calendar age and - using the TruAge test-- the biological age of the subjects. That difference was initially zero, but after 4-10 months of supplementation the subjects had become 8 years younger on average. According to the test.
Mechanism
There are many theories about the possible mechanism of action of AKG. The most popular theory is that AKG inhibits ATP biosynthesis, thus mimicking the effects of caloric restriction.
Source:
Aging (Albany NY). 2021 Nov 30;13(22):24485-99.
More:
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Glycine AKG a longevity supplement? 25.08.2015
Alpha-keto acids give athletes more energy 02.10.2012
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