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Ergo-Log

08.04.2023

Does Myotor really work that well?

A few days ago we noticed something on the label of what looked like an ordinary jar of whey that we didn't know. 'Myotor', we read. After a few days of searching in the electrical library called the internet, we know roughly what kind of stuff Myotor is. But we just don't know what to make of it.


A few days ago we noticed something on the label of what looked like an ordinary jar of whey that we didn't know. 'Myotor', we read. After a few days of searching in the electrical library called the internet, we know roughly what kind of stuff Myotor is. But we just don't know what to make of it.


Myotor
Myotor is also known as LI12542F6 and RipFactor [prnewswire.com]. We will not use those names in this post.

Myotor is a proprietary herbal blend. It is a mixture of 2 extracts. It consists of 2 parts of an extract of the dried flowers of the thistle Sphaeranthus indicus and 1 part of extract of the bark of the mango tree Mangifera indica.

Both extracts have been on the market for quite some time. They are in formulas that are supposed to inhibit inflammation and alleviate type 2 diabetes.

Myotor was invented by the Indian Laila Nutraceuticals. Laila deals in patents that describe the effect of components and combinations of medicinal extracts in a variety of diseases and disorders. [justia.com]

Ten years ago we wrote about another combination patented by Laila. That was Meratrim, a mixture of extracts of Sphaeranthus indicus and Garcinia mangostana. Test subjects who used it could lose no less than 5.2 kilos in 2 months.

In 2019, researchers at Laila Nutraceuticals published a toxicological study on Myotor. [Food Sci Nutr. 2019 Jan 29;7(2):817-33.] From that study, which concluded, by the way, that Myotor was relatively safe, we took the figure below. You are looking at an HPLC content analysis from Myotor.

As you can see, mangiferin and 7-alpha-hydroxy-frullanolide are two of the main phytochemicals in Myotor.


A few days ago we noticed something on the label of what looked like an ordinary jar of whey that we didn't know. 'Myotor', we read. After a few days of searching in the electrical library called the internet, we know roughly what kind of stuff Myotor is. But we just don't know what to make of it.


A few days ago we noticed something on the label of what looked like an ordinary jar of whey that we didn't know. 'Myotor', we read. After a few days of searching in the electrical library called the internet, we know roughly what kind of stuff Myotor is. But we just don't know what to make of it.


#1 Mangiferin
Myotor consists of 2.5 percent mangiferin. In animal studies, mangiferin increases insulin sensitivity. [PLoS One. 2017 Mar 2;12(3):e0173028.] If you translate the effective doses into humans, you arrive at about 200-400 milligrams of mangiferin per day.

If you have to get this amount from Myotor, well, you're talking about 8-16 grams per day for someone weighing 80 kilos. This dose is most likely not safe.

7-alpha-hydroxy-frullanolide
Probably also due to 7-alpha-hydroxy-frullanolide by analogs, extracts of Sphaeranthus indicus improve the absorption of insulin by cells. [Pharm Biol. 2010 Dec;48(12):1371-5.] The human equivalent of the doses that would be required for this is 2-4 grams per day.


A few days ago we noticed something on the label of what looked like an ordinary jar of whey that we didn't know. 'Myotor', we read. After a few days of searching in the electrical library called the internet, we know roughly what kind of stuff Myotor is. But we just don't know what to make of it.


You won't hear us say that those doses are safe either.

Study
In the early spring of 2023, researchers at Laila published a human study in which 40 men aged 18-40 who trained in a fitness center participated as test subjects.

Half of the men took 650 milligrams of Myotor every day for 8 weeks. The other half received a placebo.

Results
The subjects taking Myotor became significantly stronger than the subjects in the placebo group. They also built up more muscle mass and lost a little fat mass.

Click on the tables for a larger version.


A few days ago we noticed something on the label of what looked like an ordinary jar of whey that we didn't know. 'Myotor', we read. After a few days of searching in the electrical library called the internet, we know roughly what kind of stuff Myotor is. But we just don't know what to make of it.


A few days ago we noticed something on the label of what looked like an ordinary jar of whey that we didn't know. 'Myotor', we read. After a few days of searching in the electrical library called the internet, we know roughly what kind of stuff Myotor is. But we just don't know what to make of it.


A few days ago we noticed something on the label of what looked like an ordinary jar of whey that we didn't know. 'Myotor', we read. After a few days of searching in the electrical library called the internet, we know roughly what kind of stuff Myotor is. But we just don't know what to make of it.


Remarkably, supplementation increased the concentration of testosterone and decreased that of cortisol.

Conclusion
Apparently, mangiferin and 7-alpha-hydroxy-frullanolide potentiate each other in a way that we have not seen before. Otherwise it is hard to imagine how such relatively small amounts can have such strong and convincing effects.

Or the sponsored study by Laila Nutraceuticals gives an exaggerated picture of the effect of Myotor. That is of course also possible.

Source:
Food Nutr Res. 2023 Jan 27;67.

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