ergo-log.com

Definition: "An ergogenic aid is any substance or phenomenon that enhances performance "

16.10.2023

By inhibiting AGEs, carnitine may slow down aging

Advanced glycation end products [AGEs] play a significant role in aging processes. Conversely, nutrients, supplements and foods that inhibit the formation of AGE may delay aging. According to an older human study, L-carnitine may be an interesting AGEs inhibitor.

Study
In 2013, Japanese nephrologists, affiliated with Kurume University School of Medicine, published a human intervention study in which they gave 32 patients with poorly functioning kidneys 900 milligrams of L-carnitine every day for 16 weeks. A control group of 38 patients received a placebo. All patients required frequent hemodialysis.

In this group of hemodialysis patients, the concentration of advanced glycation end products [AGEs] is higher than normal. Because in animal studies supplementation with carnitine reduces the formation of AGEs, [Acta Diabetol. 2007 Jun;44(2):83-90.] the Japanese wondered whether carnitine has the same effect on hemodialysis patients.

Results
Supplementation with L-carnitine increased the concentration of carnitine in the blood. Supplementation simultaneously reduced the concentration of AGEs in the skin of the test subjects by 8 percent, the table below shows. Click on it for a larger version.

Supplementation slightly worsened cholesterol balance. Carnitine supplementation may only have that effect specifically in this group. According to meta-analyses, there are indications that carnitine supplementation actually improves cholesterol balance.

The higher the concentration of carnitine in the bloodstream of the test subjects, the lower the concentration of AGEs in their skin. This suggests that higher doses of carnitine may have a stronger effect on the concentration of AGEs.

Source:
Rejuvenation Res. 2013 Dec;16(6):460-6.

More:
Carnitine makes type 2 diabetics healthier 25.06.2020
Acetyl-L-carnitine rejuvenates old muscles 19.02.2018
L-Carnitine helps centenarians build muscle mass 27.03.2012

Archives:
L-Carnitine
Longevity

AGEs | The estrogenic effect of unhealthy foods There is a link between, on the one hand, the eating of processed foods as fries and candybars, and on the other hand, the action of the female sex hormone estradiol.	The anti-AGE-ing effect of olive oil If olive oil is your main source of fatty acids, then you probably live longer.	How white button mushrooms might take the sting out of diabetes and delay aging The more glucose circulating in your body, the more AGEs are formed, the more tissues are damaged and the faster the aging process. Fortunately, there is a food that inhibits the formation of AGEs.