1950 | After a myocardial infarction, megadoses of choline keep heart patients alive

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29.07.2023

Earlier this month we wrote about the forgotten research of the American cardiologist Lester Morrison, who discovered in the second half of the last century that supplementation with a few grams of chondroitin per day significantly reduced the risk of death in heart patients. The same Lester Morrison achieved similar results with good old choline.

Choline

In January 1950 Morrison published a short article in which he reported that he had treated 230 heart patients with atherosclerosis aged 28-70 with choline or with a placebo. All patients had survive a myocardial infarction.

The 115 patients in the experimental group received a dose of choline bicarbonate [structural formula above] every day for 1, 2 or 3 years. The daily doses ranged from 6 to 32 grams per day.

These are significant amounts. Nutritionists at the American Institute of Medicine estimate that adults need 425-500 milligrams of choline daily. The best dietary sources are animal foods, such as eggs, chicken, beef and fish, but choline is also found in nuts, vegetables and grains.

With an intake of more than 6-8 grams per day, people can get a fishy body odor or become nauseous. In practice, the response to megadoses of choline varies from individual to individual. Some people can take tens of grams every day without a penny of pain, while other people feel nauseous and sick.

Results
After 3 years, 30 percent of the subjects in the control group had died. In the choline group this was 12 percent. [Quote]

Source:
Proc Soc Exp Biol Med. 1950 Jan;73(1):37.

More:
Betaine & choline | Body recompositioning nutrients that protect against cancer 13.07.2020
Phosphatidylcholine, a choline analog in eggs and meat, protects against dementia 03.10.2019
Increase your daily intake of choline, reduce your chance of Alzheimer's 01.10.2019
More choline and betaine means more muscles and less fat 16.03.2018

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Cardiovascular Health
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Choline



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