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Definition: "An ergogenic aid is any substance or phenomenon that enhances performance "
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07.07.2022 |
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St. John's wort reduces depression | Meta-study
St John's wort really works against depression. This is evident from a meta-study that combined and re-analyzed data from three dozen previously published trials.
Study
In the studies, researchers used doses that were almost always somewhere between 500-1200 milligrams of extract per day. The subjects divided these doses over 2-3 intakes per day.
The extracts that the researchers used most frequently contained 0.3 percent hypericin and 1-4 percent hyperforin.
The subjects received no other drugs.
Results
Click on the figures below for a larger version.
The depression scores in the users of St John's wort decreased significantly more than in the subjects who received a placebo. That is what the figure above tells.
According to Apaydin's metadata, the depression disappeared slightly more often in subjects in the supplementation group than in subjects who received a placebo, but the difference was not significant.
In a number of studies, the researchers compared the effects of St. John's wort with those of regular pharmacological antidepressants. Both treatments were found to be equally effective. However, users of St John's wort reported fewer side effects.
Conclusion
On the RAND Corporation website, on Apaydin's bio page, [rand.org] we found a quote from him that you see on the right.
If you use medication, you can often not use St. John's wort, we would like to add to that. Supplementation activates enzymes involved in the breakdown of more than half of the drugs prescribed by doctors, which can reduce their effect.
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