Definition: "An ergogenic aid is any substance or phenomenon that enhances performance "
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10.06.2022 |
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SAMe mitigates major depression
Supplementing with S-adenosyl-methionine, commonly abbreviated as SAMe, improves mood, according to the supplement industry. According to an Italian review study, this may well be true.
Study
The dosage in the trials ranged from 200 to 3200 milligrams per day. The route of administration was usually oral.
The trials lasted 2 to 12 weeks.
Click on the table below for a larger version.
Results
4 trials concluded that SAMe performed as well as a pharmacological antidepressant. 2 trials saw no difference between SAMe and a placebo.
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Mechanism
Conclusion
"Nonetheless, they may provide a useful strategy for migraineurs who need to treat headaches and who are overweight and/or experience a weight increase as a side effect of cyclic prophylactic treatments for migraines."
"The existing findings are encouraging, but further, well-designed, randomised, controlled clinical trials are needed to provide definitive evidence about SAMe efficacy and tolerability, both as monotherapy and as adjunctive treatment."
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