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31.08.2023

More vitamin E, less dementia

The day before yesterday we wrote about a Chinese-American epidemiological study that suggested that a relatively high intake of vitamin E - about as high as it should be according to nutritional guidelines - protects people over 60 from cognitive decline. Does this also apply to vitamin E in supplements? According to a Chinese meta-study, this is indeed the case.

Study
Epidemiologists at Gansu Provincial Hospital in China traced 15 previously published studies in which researchers had looked at vitamin E intake and the risk of dementia and Alzheimer's disease. They aggregated the outcomes and reanalyzed them. The result was published in 2022 in Frontiers in Aging Neuroscience.

Results
A relatively high intake of vitamin E reduced both the risk of dementia in general and Alzheimer's in particular by 21 and 22 percent respectively compared to a relatively low intake. This applied to both the intake of vitamin E from regular foods and vitamin E from supplements.

All the figures below relate to the risk of dementia.

Not all studies were equally good. But it made no difference whether the researchers used only studies for their meta-analysis that scored more than 7 on the Newcastle-Ottawa Scale - and were therefore rated 'good'.

The researchers also looked at whether they could find indications of bias by concealing less desirable research results. They did not find it, as the figure below shows.

The links the researchers found between vitamin E and dementia were not substantially different from those between vitamin E and Alzheimer's disease.

Conclusion
"High intakes of diet or vitamin E supplements can significantly reduce the risk of dementia", summarize the researchers. "Therefore, the elderly can reduce the risk of dementia by appropriately increasing foods rich in vitamin E, but also pay attention to the toxic side effects of vitamin E."

The researchers also looked at whether they could find indications of bias by concealing less desirable research results. They did not find it, as the figure below shows.

Source:
Front Aging Neurosci. 2022 Aug 1;14:955878.

More:
After 60, a high intake of vitamin E maintains cognitive abilities 29.08.2023

Archives:
Alzheimer's & Dementia
Vitamin E
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