Are supplements companies messing with kratom?
There may be something wrong with the kratom supplements that some pharmacological bodybuilders use to intensify their workouts. According to American toxicologists, they contain considerably more active substances than you would expect in natural kratom extracts.
Toxicologists from the University of Massachusetts Medical School bought a number of kratom supplements, and determined in their lab how much mitragynine and 7-hydroxy-mitragynine they contained. These are the main active substances in kratom, of which 7-hydroxy-mitragynine has the most powerful analgesic effect. According to fundamental research, 7-hydroxy-mitragynine clings to the opiod receptor 17 times better than good old morphine.
The table below shows the concentrations of mitragynine and 7-hydroxy-mitragynine that the researchers found in the kratom products. They compared the values with the concentrations that Japanese researchers previously found in dried kratom leaves.  in the table refers to the Japanese publication. [Forensic Toxicology 2009 July 27(2):67-74.]
"We have found multiple packaged commercial Kratom products to contain artificially elevated concentrations of 7-hydroxy-mitragynine, the alkaloid responsible for Mitragyna speciosa's concerning mechanistic and side effect profile", the researchers write.
"The amount of 7-hydroxy-mitragynine exceeded that found in naturally occurring material by up to 500 percent.
"The recognition that 7-hydroxy-mitragynine is itself a metabolite further supports the notion of excessive concentrations being due to artificial addition of this psychoactive substance."
"Federal regulations surrounding possession and use of Kratom are lacking. This study describes a unique form of product adulteration, which stresses the importance of increased dietary supplement oversight of Kratom-containing supplements."
Playing the devil's advocate
We are well aware that some supplement companies put pharmacological substances in their products without even blinking an eye. But because we also use fish oil capsules [which make you more honest] [Physiol Behav. 2009 Jan 8;96(1):180-3.] we feel compelled to show you the figure below. It is from the Japanese publication above.
The figure shows how, after the Japanese made their extract with methanol and sonication, the concentration of 7-hydroxy-mitragynine in the extract increases if the researchers simply leave the preparation overnight.
You wonder how much 7-hydroxy-mitragynine the Japanese would have found if they had left their product for a week. Or two weeks. Or even longer.
J Med Toxicol. 2016 Dec;12(4):341-9.
Human study | This is the analgesic effect of kratom 18.07.2020