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03.02.2018

L6N, the stamina factor in moso bamboo

The flavonoid luteolin-6-neohesperidoside [L6N] is found in the leaves of the rapidly growing and edible bamboo species Phyllostachys edulis. In a high, but not extreme dose, that substance increases the endurance of test animals. Chinese researchers at the University of Zhejiang write about this in Nutrients.

Phyllostachys edulis
Phyllostachys edulis or moso bamboo is a giant bamboo. On a warm day he can grow up to 1 meter. Because this type of bamboo is hardy, it does well in European and American gardens.

Study
The researchers made rats swim every day for 21 days until they were so exhausted that they were about to drown. Some of the rats did not receive supplements [MC], some rats received of a large amount of vitamin C [AA100] and the rest of the lab animals recieved luteolin-6-neohesperidoside.

If the rats had been human beings of 85 kilos, the animals in the AA100 group would have got 1200 milligrams of vitamin C daily. The rats given luteolin-6-neohesperidoside would have received 300 [LN25], 600 [LN50] or 900 mg flavonoid [LN75] daily.

The animals were given the substances, dissolved in water, orally. The researchers let the rats swim 1 hour after administration of the supplements.

Results
On the last day, the rats that received the higher doses of luteolin-6-neohesperidoside could swim twice as long as the test animals that had not received anything.

In these animals' muscles and liver, the researchers found less free radicals [ROS], and less inflammatory factors such as TNF-alpha and interleukin 1-beta.

The supplementation had increased the activity of NRf2. NRF2 is a kind of molecular sensor that tells cells if aggressive molecules are active. As a result, cells start to produce protective enzymes. One of these enzymes is HO-1, which protects muscles against the effects of intensive physical activity.

Vitamin C had almost the same effects as luteolin-6-neohesperidoside. As a result, the question remains whether luteolin-6-neohesperidoside works in humans. In humans, high doses of antioxidants such as vitamin C may inhibit adaptation processes in muscles. Well, that's what we think.

Conclusion
The researchers, however, are less doubtful than we are. "All the results demonstrated that the administration of luteolin-6-neohesperidoside could significantly improve the endurance of rats", they wrote. "Moreover, luteolin-6-neohesperidoside clearly prevented the dysfunction of the liver and skeletal muscle induced by oxidant stress by regulating inflammatory and oxidative reactions."

"The underlying mechanisms responsible for the antifatigue effect of luteolin-6-neohesperidoside involves mainly the modulation of oxidative stress and inflammation by activating the Nrf2 pathway."

"These results suggest that luteolin-6-neohesperidoside has significant health benefits due to its antifatigue activity, which provided scientific evidence for further development of natural products for prevention and treatment of diseases related to fatigue."

Source:
Oxid Med Cell Longev. 2017;2017:3159358.

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