Definition: "An ergogenic aid is any substance or phenomenon that enhances performance "
Curcumin enhances the effect of running on muscle cells
Intensive exercise makes your muscle cells function at a higher level. They will repair themselves better and protect themselves better against damage, generate more energy and absorb more glucose from the blood. Supplementation with a large dose of curcumin enhances these effects, researchers at the University of Firat in Turkey discovered. The researchers experimented with rats, not with people.
Supplementation with curcumin reduced the concentration of glucose and lactic acid in the blood, the researchers discovered. This already gives an indication of how curcumin might work, but the researchers found more precise information when they looked at molecular changes in rats' muscle cells. Curcumin had increased the production of a number of signaling molecules that play a prominent role in adaptation processes in active muscle tissue.
In trained muscle tissue, muscle cells produce less of the inflammatory factor NF-kappaB. As a result of this decrease, muscle cells break down less quickly and are more sensitive to insuline. Curcumin enlarged this decrease.
SIRT1 makes cells to repair themselves, PGC-1-alpha pushes cells to produce more mitochondria, allowing them to convert more nutrients into energy. Because of the supplementation with curcumin, the trained rats started to produce an extra large amount of both molecules.
GLUT4 is a molecule that enables cells to take up glucose. Once again the trained rats had started to produce an extra large amount of that molecule through supplementation with curcumin.