House dust mite allergy? Running helps
Are you allergic to this mean bastard called Dermatophagoides pteronyssinus? He is also known as the house dust mite. Then run. Three times a week, 30 minutes will do. According to a small human study from Thailand, running will not cure your allergy, but it will reduce the severity of your allergic reaction.
The researchers, who were by the way affiliated with Chulalongkorn University in Bangkok, divided 27 subjects aged 18-45 with an allergy to house dust mites into 3 groups.
One group, the control group, did not do anything for 8 weeks. The other two groups ran for half an hour 3 times a week with an intensity of 65-70 percent of the maximum heart rate. One of these experimental groups took a placebo every day [Ex], the other took 2 grams of vitamin C every day [Ex + Vit.C].
Before [Pre-test] and after [Post-test] the 8-week period, the researchers exposed the test subjects to house dust mites, and measured for an hour the extent to which the subjects were suffering from runny nose, itching, sneezing or a stuffy nose, and then gave the test subjects a score. The higher the score, the more serious the complaints.
In the groups that had been trained [Ex and Ex + Vit.C], the response to house dust mite exposure was lower than in the control group [Con]. Supplementation with vitamin C had no effect.
Analysis of the subjects' blood showed that cardio training inhibited the increase in the production of interleukin-4 after exposure, and stimulated the production of interleukin-2.
Interleukin-4 makes the immune system attach labels to cells that are subsequently attacked by the immune system. In case of allergy, the activity of interleukin-4 is increased. Interleukin-2 stimulates the development of immune cells that do the actual work, and clean up cancer cells and germs.
"The present study demonstrate that both aerobic exercise training alone and aerobic exercise training combined with vitamin C have beneficial effects in allergic rhinitis patients by reducing rhinitis symptoms", write the researchers. "The extensive benefits on immune function were to improve cytokine deviation by increase IL-2 and decrease IL-4."
"This study clearly confirms that aerobic exercise significantly improved clinical of allergic rhinitis and cytokine profiles. However, due to the limited power of our small sample size, we were unable to determine as to whether adding vitamin C supplementation to exercise would confer a greater benefit than exercise alone in improving the clinical response in allergic rhinitis patients. A larger randomized controlled trial is thus warranted."
Asian Pac J Allergy Immunol. 2018 Aug 13. doi: 10.12932/AP-040417-0066. [Epub ahead of print].
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