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16.06.2023

Hop extract increases bone density

Supplementation with an extract of hops - Latin name: Hupulus lumulus - increases bone density in post-menopausal women. The effect is probably large enough to reduce the risk of a bone fracture by 40 percent.


Supplementation with an extract of hops - Latin name: Hupulus lumulus - increases bone density in post-menopausal women. The effect is probably large enough to reduce the risk of a bone fracture by 40 percent.


Study
Researchers from the French company Givaudan France Naturals gave 100 postmenopausal women aged 50-85 a supplement containing half a gram of calcium and 400 IU of vitamin D3 every day for 48 weeks.

Half of the women received these nutrients in a supplement that also included an extract of hops. It contained 100 micrograms of 8-prenylnaringin, 110 micrograms with 6-prenylnaringenin, 1.25 milligrams of xanthumol and 2.94 milligrams of isoxanthylnaringenin.

Givaudan markets a supplement with exactly the same composition. It's called Lifenol. So we are talking about a sponsored study.

The main active substance in Lifenol is probably 8-prenylnaringin. To our knowledge, 8-pregnylnaringenin is the most potent phytoestrogen in our diet. [J Steroid Biochem Mol Biol. 2004 Jul;91(3):99-109.]

Results
After menopause, bone mass decreases relatively quickly in many women. According to DXA scans, supplementation with the hop extract not only seemed to slow down, but even reverse this process.


Supplementation with an extract of hops - Latin name: Hupulus lumulus - increases bone density in post-menopausal women. The effect is probably large enough to reduce the risk of a bone fracture by 40 percent.


Supplementation with an extract of hops - Latin name: Hupulus lumulus - increases bone density in post-menopausal women. The effect is probably large enough to reduce the risk of a bone fracture by 40 percent.


Supplementation with an extract of hops - Latin name: Hupulus lumulus - increases bone density in post-menopausal women. The effect is probably large enough to reduce the risk of a bone fracture by 40 percent.


The researchers also had the women complete the Short Form Health Survey-36. This showed that the supplement group functioned better physically.

Conclusion
Based on other research, the researchers estimate that in subjects whose supplementation resulted in an increase in bone density of at least 1 percent, the risk of a bone fracture decreased by at least 40 percent.

Source:
Nutrients. 2023 Jun;15(12):2688.

More:
Xanthohumol, a life extender in hops and beer 27.03.2021
Humulus lupulus supplement combats depression, anxiety, and stress 02.09.2018
8-Prenylnaringenin: a natural anabolic for women 18.01.2013

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