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29.05.2023

Gram D-chiro inositol gives men more testosterone

We wrote in 2021 that supplementation with a substantial dose of D-chiro-inositol raises testosterone levels and lowers estradiol levels in people over the age of 65. An attentive reader sent us a study in which D-chiro-inositol had a similar effect on the endocrine system of men aged 30-65 years.

Study
In in vitro studies, D-chiro-inositol increases testosterone production when cells are exposed to insulin. [J Clin Endocrinol Metab. 1998;83(6):2001-5.] In addition, D-chiro-inositol reduces the activity of aromatase, the enzyme that converts testosterone into estradiol. [Reprod Biol Endocrinol. 2016;14(1):52.]

Does this imply that D-chiro-inositol supplementation increases testosterone production in men? Italian endocrinologists from the Systems Biology Group Lab attempted to answer that question with a small trial, in which 10 men aged 30-65 with normal, but not very high testosterone levels acted as test subjects.

The men took 2 capsules containing 500 milligrams of D-chiro-inositol daily for a month. In total, the men therefore took one gram of D-chiro-inositol per day.

The Italians did not use a control group.

Results
Supplementation had no effect on the concentration of FSH and LH in the subjects' blood, but it did affect their total testosterone level, which rose by an average of 23.4 percent. The supplement literally worked on all men.

DHEA levels also rose.

At the same time, the estradiol level fell by an average of 14.4 percent, which was not statistically significant. The estrone level due to supplementation with D-chiro-inositol dropped by 85 percent. This decrease was statistically significant.

Conclusion
"Altogether, these findings lead the authors to propose that D-chiro-inositol may act as a down-regulator of the aromatase activity", write the Italians.

"Additional studies with a larger cohort of patients are required to confirm our findings, but also to evaluate the effects on prostate and sperm parameters and to understand the underlying molecular mechanisms involved in D-chiro-inositol activities."

"The complex activities exerted by D-chiro-inositol offer promising opportunities. D-chiro-inositol may be administered at different dosages and length of treatment to treat in men mood disorders or reduced libido associated to low testosterone levels, hypogonadotropic hypogonadism, overweight or obesity."

Source:
Basic Clin Androl. 2021 Jun 3;31(1):13.

More:
Inositol alleviates severe depression 03.03.2023
Obese with a fatty liver? This dose of myo-inositol makes you healthier 27.02.2023
Two capsules of D-chiro-inositol per day: more testosterone, less estradiol, less body fat and greater insulin sensitivity 16.11.2021

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