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Definition: "An ergogenic aid is any substance or phenomenon that enhances performance "
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18.05.2025 |
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Creatine makes one fatty liver healthier - but not the other | Animal study
If you have a fatty liver due to unhealthy eating and lack of exercise, supplementing with creatine may very well be a solution. But if you have a fatty liver due to chronic alcohol abuse, you may be better off not taking creatine. This is suggested by an animal study published in Life Sciences in 2022.
Study
Another group of mice was fed regular food but consumed alcohol daily. These mice also developed fatty liver disease. In medical jargon, such an affected liver is called alcoholic fatty liver [AFL].
When the livers of the mice were fatty, the Brazilians also gave half of the mice in both groups creatine. The supplementation period lasted 28 days.
If the mice had been adults, they would have received 50 grams of creatine daily. Of course, this dose does not occur in practice.
Results
Apparently, creatine stimulates fat oxidation by the liver.
As for the effect of creatine on alcoholic fatty liver, this does not apply.
Creatine supplementation actually increased the amount of fat in the alcoholic fatty liver. Supplementation also enhanced the increase in the enzymes AST and ALT in the blood and the increased activity of TNF-alpha in the liver. Creatine supplementation apparently made the alcoholic fatty liver even more unhealthy.
Conclusion
"The creatine intake in preclinical models is higher than nonsupplemented human diet. Thus, this is also not an alert to people that combine ethanol and food containing creatine."
"This study does however raise the question of whether creatine supplementation and heavy drinking might synergistically promote liver damage in humans. Such a study is warranted."
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