How a combination of NADH and Q10 fights fatigue
People struggling with chronic fatigue may react well to supplements containing NADH and Q10 Spanish researchers at the Universitat Autonoma de Barcelona discovered when they did a sponsored study. The results of the Spanish study would also seem to indicate that NADH is probably interesting for athletes too.
NADH & NAD+
NADH is the reduced form of the co-enzyme NAD+. NAD+ plays an important role in cells for all sorts of enzymes that are involved in processes of energy burning and repair. At present, anti-aging researchers are studying whether it is possible to improve physical performance and delay aging by increasing the concentration of NAD+ in cells. Supplementation with nicotinamide riboside is one way. Supplementation with NADH is another.
The researchers did an experiment with 73 women, aged 18-65, all of whom were struggling with chronic fatigue syndrome. They gave half of the women a placebo daily, and the other half got a daily 20 mg NADH [structural formula shown below], 200 mg Q10 [structural formula on the right], 80 mg phosphatidylserine and 160 mg vitamin C.
The supplements that the researchers used were made by Vitae Natural Nutrition. [vitae.es] Vitae Natural Nutrition sponsored the study, and one of the company's employees was also research leader.
During the eight weeks that the experiment lasted, the subjects reported less fatigue when they filled in the Fatigue Impact Scale [FIS]. The maximum score in the test is 160, the lowest 0. The lower you score, the less tired you are.
The effect of the supplementation was significant but not overwhelmingly large.
The researchers got the subjects to cycle to the point of exhaustion on two occasions: just before starting the supplementation period and after they had taken the supplement for the last time. During the test the subjects had to pedal a little harder each successive minute.
The researchers noticed no significant improvement in the amount of time that the subjects managed to keep cycling for. They did notice, however, that the heart rate of the supplement users went down significantly during the test. This did not happen in the placebo group.
In another publication [Antioxid Redox Signal. 2015 Mar 10;22(8):679-85] the researchers described how supplementation with NADH and Q10 probably alleviates chronic fatigue syndrome. In that article the Spanish explain that the supplement boosted the concentration of NADH in the cells, and reduced the number of blood markers for free radical activity.
In addition, supplementation boosted the concentration of ATP and the activity of the enzyme citrate synthase in the cells. Citrate synthase is a key enzyme in the citric acid cycle, a complex reaction in which cells convert nutrients into energy.
"This 8-week, randomized, double blind, placebo-controlled trial suggested that the CoQ10 plus NADH supplementation may be a safe, well tolerated and potentially useful treatment", the researchers summarised. "CoQ10 plus NADH supplementation improved significantly reducing maximum heart rate during the ergometer stress test and also on perceived fatigue in the chronic fatigue syndrome."
"Larger multicenter trials with longer term follow-up interventions in more homogenous chronic fatigue syndrome populations are warranted."
Clin Nutr. 2016 Aug;35(4):826-34.
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