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Coffee ingredient chlorogenic acid blocks insulin's pro-aging effect

Coffee ingredient chlorogenic acid blocks insulin's pro-aging effect
Coffee drinkers live a little longer than people who do not drink coffee. That could well be related to the phyochemical chlorogenic acid. Coffee drinkers get the substance with hundreds of milligrams per cup inside. According to a Chinese animal study, chlorogenic acid reduces the aging stimulus of insulin and may even prolong life.

Chinese biochemists, affiliated with the Kunming Institute of Botany, experimented with the model organism Caenorhabditis elegans, a little roundworm. The reserachers added different concentrations of chlorogenic acid to the medium in which the worms lived.

Supplementation with chlorogenic acid prolonged the life of the worms. Remarkably, the lowest dose - 50 micromol - seemed to work best. 'More' in this case is therefore not synonymous with 'better'.

Coffee ingredient chlorogenic acid blocks insulin's pro-aging effect

Coffee ingredient chlorogenic acid blocks insulin's pro-aging effect

At a temperature of 35 degrees Celsius, Caenorhabditis elegans dies as e result of heat stress. Chlorogenic acid slowed down the dying of the animals, the figure above shows. This may imply that chlorogenic acid also protects against other forms of physiological stress, such as the activity of free radicals.

On the bottom left, you see that chlorogenic acid inhibited the action of the insulin-activated AKT signaling molecule. Below right you can see that the life-prolonging effect of chlorogenic acid was not present in a Caenorhabditis elegans variant with a deviant daf-16 gene.

Coffee ingredient chlorogenic acid blocks insulin's pro-aging effect

To cut a long story short, this strongly suggests that chlorogenic acid extends life span by inhibiting insulin's pro-aging stimulus. It makes you wonder wonder what would happen if you combine chlorogenic acid with glucosamine...

"We found that chlorogenic acid, consistent with its effect on agerelated disease, could extend the lifespan of Caenorhabditis elegans via insulin/ insulin-like signaling pathway", the researchers summarize.

"Given the wide usage and the beneficial effect of chlorogenic acid for human health, the lifespan extension effect of chlorogenic acid in mammals, including humans, is worth to be further investigated. Our findings may serve as a starting point for developing the possibility of nutraceutical or pharmaceutical interventions in the aging process."

J Gerontol A Biol Sci Med Sci. 2017 Apr 1;72(4):464-472.

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