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19.01.2025

Cannabidiol supplementation makes Natural Killer cells better cancer fighters

Natural killer cells attack cancer cells - and possibly viruses - more vigorously with cannabidiol supplementation. This is evident from a 2023 American trial, in which subjects were given 50 milligrams of cannabidiol daily.

Study
Jacob Kisiolek, a nutrition scientist at the University of Northern Colorado, divided 28 healthy subjects into two groups. For eight weeks, one group took a placebo daily, while the subjects in the other group took a capsule containing 50 milligrams of cannabidiol daily.

Kisiolek used a product from Six Degrees Wellness, but that company did not sponsor the study. Kisiolek's university did.

Just before and on the last day of supplementation, the researchers took blood from the subjects and extracted immune cells from it - more precisely: peripheral blood mononuclear cells. Then they added K562 cancer cells. The ratio of immune cells to cancer cells was 1:10.

Results
After the supplementation period, significantly fewer cancer cells survived in the blood of the test subjects who had received cannabidiol.

Based on previous studies, the researchers assume that cannabidiol had mainly affected the Natural Killer cells. NK cells have CB2 receptors, with which cannabidiol can interact.

The quality of sleep increased due to supplementation with cannabidiol, as you can see above.

The researchers suspect that this effect is caused by cannabidiol reducing the release of the control hormone CRF via the CB1 receptor in the hypothalamus. This reduces the release of cortisol and therefore improves sleep.

We ourselves, ignorant and not hindered by much knowledge, suspect that the mechanism is simpler. We suspect that the increase in sleep quality has little to do with CB1 receptors, but with CB2 receptors in the brain's sleep centers.

Conclusion
"These results collectively support the notion that low dose cannabidiol supplementation may offer benefits in enhancing sleep quality in humans and improving immunosurveillance against cancer cells in situ", write the researchers.

Source:
Nutrients. 2023 Sep 27;15(19):4173.

More:
Cannabidiol may protect against SARS-CoV-2 infection 27.06.2022

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Preventing & Surviving Cancer
Boosting Immunity
Cannabidiol
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