Steroid users are more vulnerable to the coronavirus
Ever since the outbreak of the coronavirus, well-informed anabolic experts [YouTube] [YouTube] have been telling juicers that anabolic compounds might increase their chance of a serious corona infection. According to recent scientific studies, they are probably right.
Androgenic activity & corona
Women with the endocrinological disorder PCOS produce more androgens than normal. If these women are infected with the coronavirus, the symptoms appear to be more severe than in women without PCOS. [J Eur Acad Dermatol Venereol. 2021 Feb;35(2):e101-e104.]
5-alpha reductase blockers inhibit the conversion of testosterone and molecules similar to it into the androgenic steroid DHT. If you give men with severe covid-19 reductase inhibitors, their symptoms will become less serious. [J Eur Acad Dermatol Venereol. 2021 Apr;35(4):e243-e246.] [J Eur Acad Dermatol Venereol. 2021 Jan;35(1):e13-e15.]
Less androgenic activity in the bodies of men with covid-19 apparently improves their chances. Some researchers suspect this is because androgens activate TMPRSS2. This enzyme makes cells produce more ACE2-receptors that allow the coronavirus to slip in, and also seems to make it easier for the virus to replicate.
Does this also mean that athletes who use anabolic steroids are more likely to have complications or even a fatal coronavirus infection? Yes, Brazilian endocrinologists at the Federal University of Sao Paulo write in BMJ Case Reports.
Oxandrolone & proxalutamide
The Brazilians base themselves on the case of a 28-year-old bodybuilder with a severe covid-19 infection. The case was remarkable, because the man had no risk factors. His parents did, were infected, but the virus was not able to give them serious symptms. Why then the bodybuilder became quite ill? When the endocrinologists examined him, he had been taking 40 milligrams of oxandrolone every day for a month.
The doctors got the man to stop his oxandrolone course and also gave him the anti-androgen proxalutamide. Proxalutamide is also an experimental covid-19 drug for men. [Research Square; 2020. doi: 10.21203/rs.3.rs-135303/v1.]
The doctors gave the bodybuilder a single dose of 600 milligrams of proxalutamide. Then the bodybuilder was given 200 milligrams every day for a week.
As early as 24 hours after administration, the bodybuilding reported that he felt significantly better. At the same time, various markers in his blood had visibly improved in that short time.
BMJ Case Rep 2021;14:e241572.
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