Definition: "An ergogenic aid is any substance or phenomenon that enhances performance "
Delay aging without strict diet: supplement with ketones
When you fast, and also if you follow a strict low-carb slimming diet, and the body goes over to using fat as its main fuel, the concentration of ketones [structural formulas shown below] in the blood rises. One of these is beta-HG [also known as BHB]. The health-enhancing effects of fasting are partly due to the increase of BHB in the bloodstream, biologists at the University of South Florida suspect. In experiments with microscopic lab creatures they discovered that administering BHB extended life expectancy without rigorous dieting - and also that it may delay age-related diseases such as Parkinson's and Alzheimer's.
Nematodes die at a high temperature. BHB inhibited that process, as the figure above shows.
The researchers discovered that BHB supplementation has more or less the same effect at molecular level as calorie restriction does. Like calorie restriction, BHB activated pathways such as DAF-16/FOXO and SKN-1/Nrf, and longevity enzymes such as SIR-2.1 and the AMPK-sub unit AAK-2. [AMPK consists of three proteins or sub units.] BHB administration had no effect if the researchers blocked the pathways or the enzymes, nor did it add anything if the nematodes were already on a drastically reduced calorie intake.
BHB inhibited the accumulation of the protein alpha-synuclein in NL5901 nematodes. Alpha-synuclein is found mainly in the brain, and in people suffering from Parkinson's disease the concentration in the brain increases. That would suggest that BHB can inhibit the development of Parkinson's disease.
In another experiment the researchers gave the nematodes the toxic protein amyloid-beta [Abeta]. The amount of this protein in the brain accumulates in people with Alzheimer's. The nematodes stopped moving several hours after being given the protein. The amount of time this took was longer when the nematodes were also given BHB. That would suggest that BHB can inhibit the development of Alzheimer's.