Definition: "An ergogenic aid is any substance or phenomenon that enhances performance "
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02.04.2014 |
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Curcumin is a mild anti-oestrogen
Curcumin, the main bioactive substance in turmeric, inhibits the production of estradiol. How the anti-oestrogenic effect of curcumin works the researchers at Hubei University of Medicine in China didn't look at, but that doesn't make their in-vitro study any less interesting.
Curcumin & testosterone
This in itself is interesting of course, but the study that the Chinese published in the Iranian Journal of Reproductive Medicine shows that curcumin is even more interesting – even though the authors were interested in something totally different from longevity, men, anabolic hormones and sport. The Chinese were looking for a safe and cheap medicine for endometriosis.
Curcumin & estradiol
The Chinese researchers had previously discovered that curcumin inhibited the growth of endometrial cells in lab animals. [Int J Mol Med. 2011 Jan; 27(1): 87-94.] They wondered whether that was because curcumin has an anti-oestrogenic effect.
Study
The figure below shows that curcumin reduced the concentration of estradiol [chemical structure above] in the cells compared with cells not exposed to curcumin.
The anti-oestrogenic effect of curcumin increased the longer the exposure lasted, and of course the higher the concentration of curcumin used. According to the researchers the anti-oestrogenic effect of curcumin only starts to become interesting above a concentration of 30 nanomoles/ml.
If you take supplements designed to boost the bioavailability of curcumin, then the concentration of curcumin in your blood should probably come pretty close to that of 30 nanomoles/ml.
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