Definition: "An ergogenic aid is any substance or phenomenon that enhances performance "

about us





Can oranges extend your life?

Can oranges extend your life?
It could very well be that oranges have a life-extending effect. Chinese nutrition scientists at South China University of Technology write this in Molecules. The Chinese did experiments with the nematode Caenorhabditis elegans, a popular model organism in anti-aging research.

The researchers bought orange from the supermarket and used them as raw materials for their extracts. The researchers then put those extracts at different concentrations in the culture medium of their nematodes, and then determined how long the animals could live.

The figure below shows which substances were contained in the extracts according to HPLC. Most subtances will probably be familiar to the readers of this free web magazine. Click on the figure for a larger version.

Can oranges extend your life?

At a concentration of 100, 200 and 400 mg of orange extract per ml of nutrient medium, the worms lived 10.5, 18.0 and 26.2 percent longer, respectively, than worms that were not exposed to extracts.

Can oranges extend your life?

Can oranges extend your life?

The extracts not only extended the life span of the nematodes, but also their health span. The animals remained vital longer.

The researchers determinded that oranges extend lifespan in two different ways. On the one hand, they inhibit the 'aging gene' age-1, stimulating the production of detoxifying and protective enzymes such as SOD and catalase. These enzymes clean up aggressive molecules and prevent them from damaging cells. At the same time, oranges also activate the MAPK pathway, stimulating cells to develop, grow and divide. [Figure]

"These findings revealed that orange extracts have potential anti-aging effects through extending the lifespan, enhancing stress resistance, and promoting the healthspan," the researchers write. They make no secret of thinking about commercial applications of their discovery. They call orange extract "a potential anti-aging candidate in the food industry".

The researchers were funded by the Chinese government.

Molecules. 2020 Jan 15;25(2):351.

The stimulatory effect of orange oil aromatherapy 27.06.2017
Eat citrus fruit for strong bones 04.03.2012
Sinetrol: lose a pound a week with orange supplement 23.01.2009


Quercetin is a geroprotector Lion's Mane as a life extender Fisetin, the life-extender in cucumber, makes senescent cells disappear from the body

Quercetin is a geroprotector
If you take a capsule of quercetin once a week, you probably will not prolong your life. No sir. But perhaps this weekly dose will ensure that you stay healthy longer.

Lion's Mane as a life extender
This is suggested by animal studies published by the research department of Taiwanese manufacturer Grape King Bio in PLos One.

Fisetin, the life-extender in cucumber, makes senescent cells disappear from the body
Everyday foods such as tea, onions, apples and cucumbers contain fisetin, a flavonoid that is very similar to quercetin.