Can a few hundred mils of caffeine boost the anabolic effect of oxandrolone?
Imagine: you're a careful user of anabolic steroids. You occasionally take a course of oxandrolone only, and that's all you want. If this is your way of doing things, then Portuguese doping researchers may have discovered something that'll interest you. They suspect that you can get more out of oxandrolone if you take extra caffeine.
The Portuguese, who work for the doping lab Laboratorio de Analises de Dopagem, were tipped by the police that some Portuguese steroids users swear by a combination of caffeine and oxandrolone. The researchers were curious to know more about the potential use of this combination, so they consulted the literature.
They came across studies which show that caffeine can boost the uptake and effect of paracetamol. [J Clin Pharmacol. 2007 Jun;47(6):715-26.] So, they reasoned, might caffeine have the same effect when taken with oxandrolone?
To answer this question the researchers performed an experiment in which they gave a subject, whose caffeine consumption was a normal three small espressos a day, a miniscule quantity [0.4 mg] of oxandrolone.
The researchers then monitored the amount of caffeine, oxandrolone and the inactive oxandrolone metabolite epioxandrolone [structural formula shown here] in the subject's urine for the next 40 hours. The figure below shows the amounts found in the first 14 hours. Click on it for the full figure.
The researchers then repeated the experiment, but gave the subject 300 mg caffeine in pill form. The figure above [click on it for a complete figure] shows that the amount of oxandrolone and epioxandrolone rose by a factor of 20 and 15 respectively.
The researchers think their experiment may show that caffeine causes a considerable improvement in the uptake of oxandrolone by the body. "Practically this means that similar concentrations/effects may be achieved using lower dosages", they write. "Other anabolic steroids should also be investigated."
Laboratorio de Analises de Dopagem, IDP, Lisboa, Portugal. B. Salema, J. Ruivo, X. de la Torre, M. Sekera, L. Horta. Oxandrolone excretion: effect of caffeine dosing. Published: www.adop.pt.
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