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04.05.2024

In this animal study, D-pinitol prevents and inhibits cancer

We have been boring our three readers for quite some time now with the insulin-like effect of D-pinitol, an analogue of inositol found in beans. Because we do have a rudimentary form of empathy, despite our nerdy mindset, we know that our readers crave something different. So today we read an animal study in which D-pinitol prevented and slowed breast cancer.

Study
In 2015, pathologist Thamaraselvan Rengarajan, affiliated with Universiti Sains Malaysia, published an animal study in which he injected female lab rats with DMBA, a substance that causes breast cancer.

Rats in a control group did not receive DMBA.

For 13 weeks after DMBA administration, half of the rats in both groups received a large oral dose of D-pinitol daily. If the rats had been adult humans, they would have been given about 2 grams of D-pinitol daily.

Results
Tumors developed in literally all rats that were given the carcinogenic DMBA. The researchers did not find any tumors in the control group. This was also the case with the rats given D-pinitol.

If the rats were given both DMBA and D-pinitol, tumors developed in only 40 percent of the animals. The tumors in the DMBA + D-pinitol group were also a significant 31 percent smaller than the tumors in the DMBA group.

Mechanism
In the breast tissue of the rats that had received both DMBA and D-pinitol, the researcher found less activity of Nf-kappaB and more activity of the suicide enzyme caspase-3 than in the rats in the DMBA group. In addition, D-pinitol activated the DNA repair protein p53.

Conclusion
"D-Pinitol [...] has a great potential to be used as a therapeutic agent for cancer and inflammatory conditions, and it strongly inhibits NF-kB and activates p53 and caspase-3", Rengarajan writes.

"Also, the evidence provided strongly supports the ability of D-pinitol to inhibit diverse events involved in tumor progression and clearly proves its usefulness in the treatment of cancer and inflammatory diseases."

"Additional work needs to be done to completely translate the observed preclinical findings with this important dietary agent using well-designed human clinical trials."

Source:
J Physiol Biochem. 2015 Jun;71(2):191-204.

More:
This is how you use D-pinitol 02.05.2024
The anti-diabetic effect of 600 milligrams of D-pinitol per day 30.04.2024
D-Pinitol adds nothing to creatine 03.12.2009

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Preventing & Surviving Cancer
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