Definition: "An ergogenic aid is any substance or phenomenon that enhances performance "
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18.07.2015 |
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Soya isoflavones enhance the effect of antidepressants
The isoflavones in soya enhance the effect of medicines that boost the concentration of serotonin in the brain. Researchers at the Universidad Autonoma de Santo Domingo in the Dominican Republic did an experiment with 40 women suffering from mild depression and discovered that a daily dose of several tens of milligrams of soya isoflavones not only boosted the effect of fluoxetine and sertraline, but also itself helped reduce feelings of depression.
Estradiol and depression
There are countless studies which have shown that synthetic oestrogens can help menopausal women with depression, so the researchers were curious to know whether supplementation with the plant-based oestrogens found in soya would have the same effect – whether or not they were combined with SSRIs. SSRIs are a group of antidepressants.
Study
One group of women was given a daily 10 mg of fluoxetine, the active ingredient in Prozac. [Structural formula shown above on the right.]
A third group took a daily 50 mg of sertraline, the active ingredient in Zoloft. [Structural formula shown above on the left.]
A fourth group took 50 mg sertraline daily, plus a capsule of soya extract.
Results
The figure below shows that the symptoms of depression decreased considerably in the women who only took isoflavones.
The decrease in symptoms of depressions was biggest in the women who had taken sertraline and the soya supplement.
Conclusion
The researchers formulate their conclusions cautiously. Their study was a small one, and there were no placebo groups.
Nevertheless the study is interesting. Would supplements containing L-tryptophan or 5-HTP be more effective mood boosters in combination with isoflavones.
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