This is what happens to your bones if you take 150 mg of resveratrol every day for a year

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17.04.2022

Resveratrol supplementation may well slow down aging, some scientists suspect. Whether that is really the case is a matter of debate. According to a human study, published in 2020 in the Journal of Bone and Mineral Research, resveratrol at least inhibits skeletal aging.

This is what happens to your bones if you take 150 mg of resveratrol every day for a year

Study

Australian researchers at the University of Newcastle gave 124 women aged 45-85, all of whom had been post-menopausal for at least a year, 2 doses of 75 milligrams of resveratrol every day for a year. In total, the subjects took 150 milligrams of resveratrol daily.

On another occasion, the women were given a placebo for one year.

Post-menopausal women have an increased risk of osteoporosis. Since resveratrol sabotages the catabolic switch NF-kappaB in cells in fundamental research, the researchers suspected that resveratrol supplementation could stop the breakdown of bone tissue in this group.

During the experiment, the researchers recorded the condition of the bone mass using scans.

This is what happens to your bones if you take 150 mg of resveratrol every day for a year

Results
Resveratrol supplementation increased bone density in two of the three places the researchers monitored. In another place, resveratrol supplementation significantly slowed down the breakdown of bone mass.

This is what happens to your bones if you take 150 mg of resveratrol every day for a year

Click on the table above for a larger version.

In the blood, resveratrol reduced the concentration of C-terminal telopeptide type-1 collagen [CTX]. CTX is a biomarker for bone breakdown.

Vitamin D and calcium
A small number of women supplemented with vitamin D and calcium in addition to resveratrol. In this group, the researchers found an enhanced positive effect on bone density.

"Those who took calcium with or without vitamin D had a greater increase in lumbar spine bone mass density than those who took neither", write the Australians. "Factorial analysis confirmed this observation."

"In the crossover comparison, those who took both calcium and vitamin D had a greater resveratrol-induced increase in lumbar spine bone mass density than those taking calcium only. They also had a significantly greater increase in total hip bone mass density and reduction in hip fracture risk than those taking neither calcium nor vitamin D."

The researchers do not provide figures.

Foods or supplements?
The doses that the Australians studied have been administered more often in trials. They are considered safe. However, it is not possible to get such an amount through regular foods.

Relevant dietary sources of resveratrol are red grapes and red wine. [Figure] [Br J Nutr. 2008 Jul;100(1):188-96]

According to Spanish measurements, the average resveratrol intake from regular foods is 1 milligram per day.

Source:
J Bone Miner Res. 2020 Nov;35(11):2121-31.

More:
Resveratrol analogue piceatannol for strong bones | In vitro data 09.10.2013
Animal study: resveratrol keeps astronauts' muscles and bones strong 24.09.2011

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