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Definition: "An ergogenic aid is any substance or phenomenon that enhances performance "
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30.08.2013 |
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Muscle less sore with piceatannol
The Koreans noticed the effect that piceatannol has on heme oxygenase-1 when they did tests using MCF10A cells. These are not muscle cells but epithelial cells from breast tissue. The higher the concentration of piceatannol in the test tubes, or the longer the exposure time was, the more heme oxygenase-1 [HO-1] the researchers found in the cells.
They noticed that when the genetic material in the cells was exposed to piceatannol [PIC], the messenger molecule Nrf2 transmitted a stronger signal. Apparently piceatannol boosts the activity of the protective heme oxygenase-1 via Nrf2.
Heme oxygenase-1 is activated when something in cell DNA switches on the Antioxidant Response Element [ARE]. Exposure to piceatannol resulted in Antioxidant Response Element being switched on via Nrf2, the Koreans discovered. When the researchers used siRNA to block Nrf2 this didn't happen.
Textbooks tell us that Nrf2 can induce cells to produce larger quantities of protective compounds. Apart from heme oxygenase-1 these include Gclc, GCLM, glutathione, glutathione S-transferase and UDP-glucuronosyltransferase. Sports scientists have already produced a small library of studies which show that increased activity of these enzymes reduces muscle damage and above all boosts performance.
Resveratrol has similar positive effects to those of piceatannol, but to a lesser degree. The catechol group that piceatannol possesses, and resveratrol doesn't, is responsible for the effect, the Koreans suspect. This group enables piceatannol to interact with yet another molecule: Keap1. Keap1 keeps a constant grip on Nrf2 in the cell. When piceatannol attacks Keap1, Nrf2 is released.
Good stuff, piceatannol. Watch this space.
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![Anyone following the postings on this website will not have failed to notice our recent interest in the amazing resveratrol metabolite piceatannaol. If the results of in-vitro studies are anything to go by, piceatannol is capable of inhibiting the growth of fat tissue and stimulating the growth of muscle tissue. What's more, it seems to boost the synthesis of EPO too. According to an in-vitro study done by researchers at Seoul National University in Korea, piceatannol also boosts the synthesis of heme oxygenase-1 [HO-1], an enzyme that protects athletes' muscles from muscle breakdown and soreness.](plaatjes/piceatannolstructure.gif)
![Anyone following the postings on this website will not have failed to notice our recent interest in the amazing resveratrol metabolite piceatannaol. If the results of in-vitro studies are anything to go by, piceatannol is capable of inhibiting the growth of fat tissue and stimulating the growth of muscle tissue. What's more, it seems to boost the synthesis of EPO too. According to an in-vitro study done by researchers at Seoul National University in Korea, piceatannol also boosts the synthesis of heme oxygenase-1 [HO-1], an enzyme that protects athletes' muscles from muscle breakdown and soreness.](plaatjes/piceatannolhemeoxygenase1.gif)
![Anyone following the postings on this website will not have failed to notice our recent interest in the amazing resveratrol metabolite piceatannaol. If the results of in-vitro studies are anything to go by, piceatannol is capable of inhibiting the growth of fat tissue and stimulating the growth of muscle tissue. What's more, it seems to boost the synthesis of EPO too. According to an in-vitro study done by researchers at Seoul National University in Korea, piceatannol also boosts the synthesis of heme oxygenase-1 [HO-1], an enzyme that protects athletes' muscles from muscle breakdown and soreness.](plaatjes/piceatannolhemeoxygenase2.gif)
![Anyone following the postings on this website will not have failed to notice our recent interest in the amazing resveratrol metabolite piceatannaol. If the results of in-vitro studies are anything to go by, piceatannol is capable of inhibiting the growth of fat tissue and stimulating the growth of muscle tissue. What's more, it seems to boost the synthesis of EPO too. According to an in-vitro study done by researchers at Seoul National University in Korea, piceatannol also boosts the synthesis of heme oxygenase-1 [HO-1], an enzyme that protects athletes' muscles from muscle breakdown and soreness.](plaatjes/aremechanism.gif)