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25.10.2009


Animal study: melatonin extends lifespan

Mice live longer if you add melatonin to their drinking water. Researchers at the Universidad de Granada in Spain discovered this when they did experiments with two strains of mice that age rapidly. The tryptophan analogue improves the functioning of the mitochondria in the cells, and ensures that despite the process of ageing they get sufficient amounts of the energy molecule ATP.

Study
Melatonin
The Spaniards used SAMR1 and SAMP8 mice for their experiments. These mice age faster - SA stands for senescence accelerated - and that's why researchers like them for studying ageing processes. The researchers gave the mice 10 mg melatonin per kg bodyweight in their drinking water for their whole life. Mice in the control group were given water that did not contain melatonin.

Results
The mice in the control group aged faster, probably because the cells' power pack, the mitochondria, starts to show defects. They are no longer able to neutralise harmful compounds that are produced when food components are converted into energy. The researchers noticed that the mitochondria membranes in the control group mice had more corroded fatty acids, known in the jargon as lipid hydroperoxides [LPO].


Animal study: melatonin extends lifespan


5v = 5 months of ordinary drinking water; 10v = 10 months of ordinary drinking water; 10m = ten months of melatonin.

The enzymes in the mitochondria worked better when supplemented with melatonin. The researchers had already shown this in similar experiments with other cell types, such as brain cells. The endogenous antioxidant systems in the mitochondria work better, and the mitochondria keep on producing larger amounts of the energy molecule ATP to a greater age.


Animal study: melatonin extends lifespan


The mice that got melatonin lived longer. The effect was particularly pronounced in the SAMP8 mice: the ones that got melatonin lived four months longer.

The figures below are based on survival tests with female mice. The effect is probably even bigger in male mice. Male organisms have more genetic defects than females, which is why they generally die earlier.


Animal study: melatonin extends lifespan

Animal study: melatonin extends lifespan


Conclusion
"These effects suggest that pharmacological intervention with melatonin might help to ameliorate age and age-related disorders", the researchers conclude. If you're wondering whether they work for the supplements industry, we can set your mind at rest. The research was funded by the Spanish government.

Source:
Exp Gerontol. 2008 Aug;43(8):749-56.

More:
Melatonin keeps brain cells young 04.10.2009