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20.01.2011


The extraordinary weight-loss mechanism of Hemerocallis fulva

Researchers at the Kao Corporation discovered that alcohol extracts of Hemerocallis fulva flowers [see below] force fat cells to release their contents into the bloodstream. Now there are many extracts that are capable of doing the same, but it appears that the mechanism behind the weight-loss effect of this day lilly is something special.

When the researchers added Hemerocallis fulva extracts [HE] to fat cells of rats, at first nothing happened. But when the researchers added noradrenalin [NA] to the cells, the Hemerocallis fulva extract increased the number of cAMP molecules in the fat cell. A little. Higher concentrations of Hemerocallis fulva did not lead to more cAMP.


The extraordinary weight-loss mechanism of Hemerocallis fulva
The extraordinary weight-loss mechanism of Hemerocallis fulva


CAMP is a second messenger. After adrenalin has stimulated the beta-adreno receptors, the enzyme adenylate cyclase becomes more active and the concentration of cAMP increases. And via the enzyme cAMP-dependent protein kinase A [PKA], another enzyme, hormone-sensitive lipase [HSL], also becomes active. It's this enzyme that forces fat cells to release their contents into the bloodstream.

Although giving more Hemerocallis fulva doesn't lead to more cAMP being synthesised, when Hemerocallis fulva is combined with adrenalin it does lead to more glycerol being released. That means that the fat cells release their fatty acids. As you can see, Hemerocallis fulva strengthens the effect of ordinary caffeine.


The extraordinary weight-loss mechanism of Hemerocallis fulva


Caffeine inhibits the enzyme phosphodiesterase and thus raises the concentration of cAMP. So Hemerocallis fulva needs cAMP. The researchers repeated their experiments with a cAMP analogue [dbcAMP], and the analogue and the Hemerocallis fulva extract reinforced each otherís effect. When the researchers repeated their experiments with a PKA blocker, the extract had no effect.


The extraordinary weight-loss mechanism of Hemerocallis fulva


The extraordinary weight-loss mechanism of Hemerocallis fulva


Hemerocallis fulva works in a different way from the usual weight-loss supplements, the researchers conclude: more downstream. That makes the extract an interesting ingredient for weight-loss stacks.

Traditional healers don't use Hemerocallis fulva, but the flowers of the plant are edible. You can find recipes for Hemerocallis fulva flowers on the internet. So side effects shouldn't be a problem.

Source:
Exp Biol Med (Maywood). 2009 Dec; 234(12): 1445-9.