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Study: erection supplement with L-arginine and pycnogenol works (slightly)

Men with mild erection problems, who wouldn't necessarily consider taking Viagra or Cialis, now have a non-pharmacological alternative available. Supplements containing the amino acid L-arginine and phenol-rich extracts like pycnogenol have been shown to work, according to a study by Japanese researchers that has beenpublished in Phytotherapy Research.

Regular readers of this newsletter will know how sildenafil the active ingredient in Viagra and its chemical relatives work: they inhibit the enzyme PDE-5. This is the enzyme that breaks down the signal substance cGMP in the blood vessels. So PDE-5 blockers boost the concentration of cGMP, which causes the blood vessels to relax. In the penis this means that the erectile tissues fill more easily with blood and therefore an erection is more likely to occur.

Sex supplements usually work in a different way. Instead of inhibiting the breakdown of cGMP they boost its production. This can be done by using substances that help increase the concentration of nitrogen monoxide [NO] in the blood vessels. NO is a signalling molecule that induces the enzyme guanylate cyclase to make more cGMP.


The Japanese work for Kobayashi Pharmaceutical company. [] Kobayashi produces Edicare, a dietary supplement, each pill of which contains 115 mg L-arginine, 10 mg pycnogenol and 92 mg L-aspartic acid. L-arginine is a precursor of NO, and phenols like the ones found in pycnogenol stimulate the production of NO. This combination is essential. Studies have shown that arginine on its own in a daily dose of 1.5 grams has no effect on erections. [Urol Int. 1999; 63(4): 220-3.] [BJU Int. 1999 Feb; 83(3): 269-73.] The reason for adding L-aspartic acid to Edicare escapes us right now, but no doubt it was well thought out.

Study: erection supplement with L-arginine and pycnogenol works (slightly)
The researchers gave 24 middle-aged men with mild erection problems six pills a day for a period of eight weeks. The men had to complete a standardised questionnaire on erection problems, the IIEF-5, just before starting to take the supplements, after four weeks and at the end of the eight weeks.

Before the experiment started the men in the Edicare group scored 16, indicating that they had a mild to moderate erection problem. After eight weeks their score had climbed to 17.1, the score for a mild erection problem. The lowest score on the scale is five, the highest 25.

Study: erection supplement with L-arginine and pycnogenol works (slightly)

Study: erection supplement with L-arginine and pycnogenol works (slightly)

Study: erection supplement with L-arginine and pycnogenol works (slightly)

Q2 is the score for the hardness of the erection. Score 1: almost never hard enough for sex; Score 2: occasionally hard enough for sex; Score 3: sometimes hard enough for sex; Score 4: usually hard enough; Score 5: almost always hard enough. The improvement from 3.3 to 3.6 was statistically significant. In comparison to a medicine like sildenafil, however, its effect is negligible.

Study: erection supplement with L-arginine and pycnogenol works (slightly)
The researchers do not have a convincing explanation for the noticeable rise in testosterone concentration in the saliva. They suspect that the rise was a result of the men becoming more sexually active. That seems unlikely to us. The starting value was 53.5 picogram per ml. The rise was about 60 percent.

The Japanese used a low dosage. In a 2003 Bulgarian study, in which the researchers gradually increased the dose that they gave to men with impotence problems, the subjects ended up on a daily 1.7 g L-arginine and 120 mg pycnogenol. [J Sex Marital Ther. 2003 May-Jun; 29(3): 207-13.] In this study, at the end of three months, 92 percent of the men had normal erections. The Bulgarian study resulted in the sex supplement Prelox. The manufacturer has had the effects studied several times. [PubMed]

Phytother Res. 2012 Feb;26(2):204-7..

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