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01.02.2011


Animal study: hormone balance restored with difficulty after course of monster steroid dimethandrolone

The new dimethylnandrolone undecanoate powerfully suppresses the body's own testosterone production, but after a course of this monster steroid the testes recover. At least the American research company BIQUAL says they do, in a study about to be published in the Journal of Andrology. But a close reading of this animal study reveals that the term 'recovery' should be taken with a pinch of salt.

Dimethandrolone

Dimethandrolone

Dimethyl nandrolone is an experimental steroid. It has a nandrolone skeleton with 2 methyl spines attached. Its full name is 7-alpha,11-beta-dimethyl-nandrolone 17-beta-undecanoate, but it goes by the name of dimethandrolone. The spines mean that dimethylnandrolone reacts extremely powerfully with the androgen receptors. In animal studies it has been shown to be 136 times as powerful as testosterone.

In 2007 researchers announced that they wanted to put dimethandrolone in a male contraceptive pill. [ScienceDaily Oct. 1 2007] They had done experiments with male rabbits and noticed that the rabbits became infertile after taking the steroid – and that the effect was reversible. The latter is a matter of concern for all extreme steroids, so also for dimethandrolone. Now, four years later, the study has been published in a scientific journal.

The researchers gave dimethandrolone-undecanoate in oral form to their lab animals. For 12-13 weeks the animals were given a daily 1, 2.5, 5 or 10 mg of the steroid per kg bodyweight. As a contraceptive, the 2.5 mg/kg/day was the most effective dose. With the higher doses the hormone concentration in the testes rose so much that the animals became fertile again.

The figure below shows how the amount of sperm increased again in the animals after week 13. The lower figure shows how the animals' testosterone level recovered. Hmm – recovered…. DMAU = dimethandrolone-undecanoate; vehicle = placebo.


Animal study: hormone balance restored with difficulty after course of monster steroid dimethandrolone


Animal study: hormone balance restored with difficulty after course of monster steroid dimethandrolone


Animal study: hormone balance restored with difficulty after course of monster steroid dimethandrolone


The table above shows the total testosterone and FSH production during the course of treatment [week 0-12] and afterwards [week 14-30].

If you look closely at the table you'll see that the FSH and testosterone levels in the rabbits rose again after the treatment. But if you look at the graph above the table you will notice that in week 30 the testosterone level in the 5 mg group was just above the detectable limit. The 5 mg dose is probably about what chemical athletes are likely to use.

These results are anything but reassuring. The researchers on the other hand think they are enough reason to continue the development of the new substance. It's time to try the new stuff out on non-human primates.

Dimethandrolone is already available on the black market.

Source:
J Androl. 2010 Dec 16. [Epub ahead of print].

More:
Introducing dimethyl nandrolone 08.07.2010
Monster anabolic dimethandrolone does not aromatize 30.08.2008