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30.08.2008


Monster anabolic dimethandrolone does not aromatize

The prospects for the new anabolic steroid dimethandrolone full name 7-alpha,11-beta-dimethyl-19-nortestosterone are looking increasingly good. According to researchers at US-based Bioqual, the chance of users being subjected to oestrogenic side-effects is nil. In test-tube experiments dimethandrolone did not convert into oestrogenic compounds.

Dimethylnandrolone
Dimethandrolone is a nandrolone-type of compound with two extra methyl groups on C7 and C11. These methyl groups make dimethandrolone a really powerful porcupine anabolic. Bioqual researchers published results of an animal study on dimethandrolone already in 2006. [Endocrinology. 2006 Jun;147(6):3016-26.] These showed that dimethandrolone has a powerful anabolic effect, it doesn't affect the prostate and also has a considerable progesterone-like effect. According to another study that is now four years old, dimethandrolone is 136 times more powerful than testosterone. [Bioorg Med Chem Lett. 2005 Feb 15;15(4):1213-6.]

Yeehaw.

At congresses on male contraceptives, though, researchers have reported contradictory effects on the fertility of experimental animals that were given dimethandrolone. When given low doses, animals become sterile, but apparently not when given high doses. [Science Daily October 1, 2007]

In a study that will soon appear in the Journal of Steroid Biochemistry and Molecular Biology, the researchers describe how they got 7-alpha,11-beta-dimethyl-19-nortestosterone to react in a test tube with synthetic aromatase. Aromatase is the enzyme that converts anabolic and androgenic steroid hormones like testosterone into estradiol. Aromatase is responsible for seventy percent of the gynos that you see in bodybuilders. Well, that's our estimate.

The figure below shows what happened when the researchers added testosterone to the enzyme. The amount of testosterone decreases, and the amount of estradiol increases.

Monster anabolic dimethandrolone does not aromatize

The next graph shows what happened when the researchers repeated the experiment with dimethandrolone instead of testosterone.

Monster anabolic dimethandrolone does not aromatize

Nothing at all. The oestrogen that would have been produced if the aromatase enzyme did get to work on dimethandrolone is 7-alpha,11-beta-dimethyl-estradiol. When the scientists synthesized that oestrogen and tested it in test tubes, they noticed that it interacted ten per cent less well with the alpha- and beta-receptor for estradiol than estradiol itself. If the enzyme had worked, then the oestrogenic effect would still have been considerable.

MENT

The researchers repeated the above experiment with MENT or 7-alpha-methyl-19-nortestosterone. MENT was pretty hip for a while in the anabolics scene, and it looked set to enter the market. But when it turned out not to work so well in oral form, whereas the new dimethandrolone can be taken orally, interest waned.

The graph below shows what aromatase does with MENT.

Monster anabolic dimethandrolone does not aromatize

MENT does aromatize a bit. The oestrogen that is produced, 7-alpha-methyl-estradiol, is a teeny-weeny bit stronger than ordinary estradiol.

When the researchers repeated the experiment again with 11-beta-methyl-19-nortestosterone they discovered that
11-methyl nandrolone
the nandrolone-analogue doesn't aromatize at all either. It therefore seems likely that it is the 11-beta-methyl group that prevents aromatase from interacting with dimethandrolone. Theoretically it might be possible that another enzyme, 5-alpha-reductase, the enzyme that converts testosterone in DHT, converts dimethandrolone into steroid compounds with a weak oestrogenic effect. But the researchers also think that 5-alpha-reductase won't work on dimethandrolone either. They told this during the Annual Meeting of the Endocrine Society in Toronto, Canada in 2007. In animal tests that have not yet been published, they have not discovered any signs of an oestrogenic effect of dimethandrolone.

We know enough.
A new anabolic steroid will be launched soon.

Sources:
J Steroid Biochem Mol Biol. 2008 Jun;110(3-5):214-22.
Endocrinology. 2006 Jun;147(6):3016-26.
Bioorg Med Chem Lett. 2005 Feb 15;15(4):1213-6.
Science Daily October 1, 2007.