Definition: "An ergogenic aid is any substance or phenomenon that enhances performance "
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23.12.2014 |
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Case report: cycle of 100 mg methandrostenolone per day goes badly wrong
An Australian bodybuilder who prepared for a competition by taking a hefty dose of methandrostenolone [the active ingredient in Dianabol] paid a heavy price for using steroids: he developed a hitherto unknown kind of inflammation of the liver. Researchers at the University of Sydney reported the case in Endocrine Practice. It was the first case of an inflammation of the liver induced by steroids that was accompanied by fever.
Cycle
The man said he had been preparing for a competition and had started a cycle of anabolic steroids six weeks before. He had been taking 100 mg methandrostenolone daily. The bodybuilder used Body Research's Danabol, which he had bought from a Thai web store.
He combined this with testosterone propionate and testosterone enanthate, which he injected twice a week in unknown quantities. The researchers did not find out which testosterone preparations the man used, but did know that they were meant for veterinary use.
Two weeks previously he had also started to use 20 mg tamoxifen and 2.5 mg letrozole daily, as well as 80 mg furosemide and 50 mg spironolactone. The first two substances are anti-oestrogens and the other two are diuretics.
Sick
His blood also contained high levels of the liver enzymes AST [concentration should be lower than 45 IU/l], ALT [should be lower than 47 IU/l] and GGT [should be lower than 43 IU/l]. These high concentrations all point to liver damage.
The doctors put the man on a fluid drip as he was showing signs of dehydration. In addition they took him off the substances he'd been taking immediately. Within a few days the man's liver function started to return to normal and his fever went down.
Explanation
The high dose of methandrostenolone that the bodybuilder used is probably what caused the crisis. Methandrostenolone contains a 17-alpha-methyl group, which makes anabolic steroids suitable for oral use, but which also makes them toxic for the liver.
What happened in the end to the bodybuilder the researchers do not know. They discharged him from hospital after 7 days, but after that the man did not return for any check ups.
Conclusion
"The severity of the hepatic necrosis may have been itself related to fever development. This draws attention to the potentially toxic effects of synthetic androgens alone or in combination with multiple drugs as part of the risk-taking behavior amongst some body builders."
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