Definition: "An ergogenic aid is any substance or phenomenon that enhances performance "
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23.10.2008 |
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More IGF-1 in muscle tissue with creatine
Creatine & IGF-1
IGF-1 has a strong anabolic effect. In athletes the type of IGF-1 that the muscle cells manufacture themselves is important, and this is influenced by training, amino acids and, as we now know, creatine. Different forms of IGF-1 are found in the body. Scientists suspect that there is a 'bad' kind of IGF-1, which increases the risk of cancer, and a 'good' IGF-1 that causes specific muscles to grow. Doping users inject a form of IGF-1, of which researchers don't know for sure whether it's the 'good' or 'bad' type.
Older study
The Belgians got their subjects to do weight training and gave them a daily dose of 21 g of creatine for five days. Before each training session the subjects drank a protein shake with carbohydrates.
Results
The Belgians also demonstrate in their article that creatine makes other anabolic signalling molecules in muscle cells more active, such as 4E-BP1 and p70-S6K. This leads them to conclude that "creatine supplementation could act to stimulate muscle growth, but not by a rapidly responding control system as observed after exercise plus feeding, but rather by a late-response enhancement of the anabolic status of the cell involving IGF".
Conclusion
Sources:
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