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13.02.2016

Combination glucosylhesperidin and miniscule amount of caffeine is an effective slimming aid

Japanese researchers at the House Wellness Foods Corporation have been experimenting for several years with mixtures of caffeine and glucosylhesperidin, to find ways of speeding up fat loss with no side effects. So far the Japanese have only published animal studies, but recently they published the first human study on the slimming effect of the caffeine-glucosylhesperidin combination.

Glucosylhesperidin
Glucosylhesperidin – or G-hesperidin – is a semi-synthetic compound. Chemists make the stuff by extracting hesperidin from citrus fruit peel, and then attaching it to the carbohydrate dextrin. [Structural formula shown below.]

Going by the patents, glucosylhesperidin is thousands of times more soluble than hesperidin, and so more likely to be more easily absorbable. And that makes glucosylhesperidin an interesting substance for supplements manufacturers.

Animal studies have shown that glucosylhesperidin reinforces the slimming effect of caffeine. Hesperidin, the natural analogue of glucosylhesperidin, reinforces the slimming effect of synephrine. Korean research has shown that hesperedin, the basic flavonoid in hesperidin, may also have a muscle strengthening effect. So you may see glucosylhesperidin cropping up in all kinds of bodybuilding and slimming supplements available online.

Study
The Japanese divided 75 subjects on the plump side, with a BMI of 24-30, into five groups. Over a period of twelve weeks one group took a placebo and four other groups took supplements which supplied them with a daily 500 mg glucosylhesperidin.

One of the supplements groups got only glucosylhesperidin. The subjects in the three other supplements groups took in addition to the glucosylhesperidin also 25, 50 or 75 mg caffeine.

Results
At the end of the 12 weeks, the subjects who had taken 500 mg glucosylhesperidin and 75 caffeine daily had lost fat. This supplement combination led above all to a reduction of subcutaneous fat.

The subjects who had taken 500 mg glucosylhesperidin and 75 mg caffeine lost a total of 1.43 kg weight. Four weeks later the weight had remained off.

The subjects did not change their diet. They also didn't do any more exercise than they already did. No side effects were observed.

Conclusion
"Our results showed that intake of a combination of 500-mg G-hesperidin and 75-mg caffeine for 12 weeks significantly reduced abdominal fat (especially subcutaneous fat), body weight [...] in subjects with a moderately high BMI", the researchers wrote. "Therefore, a combination of G-hesperidin and caffeine may be useful for the prevention or treatment of obesity."

Source:
Nutrition Journal (2016) 15:6.

More:
Ornithine strengthens mental effects of caffeine 29.03.2015
Tiny amount of caffeine can burn fat – when combined with tea phenols 27.08.2012
Cirsium oligophyllum extract enhances slimming effect of caffeine 14.12.2010

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