Definition: "An ergogenic aid is any substance or phenomenon that enhances performance "
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02.09.2014 |
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Does Artemisia dracunculus boost the anabolic effect of insulin?
The plant Artemisia dracunculus contains substances that inhibit muscle breakdown in obese diabetics – and that can aid muscle development, according to animal studies recently published by researchers at Pennington Biomedical Research Center in the US. So might Artemisia dracunculus also be of interest to chemical athletes?
Artemisia dracunculus
The extract that the Pennington researchers used for their experiments was PMI 5011. To avoid confusion we say right away that PMI 5011 is not interesting for supplement manufacturers. The human equivalent of the doses that the researchers gave their mice would be somewhere between 10 and 15 g per day.
The active ingredients in PMI 5011 are probably chalcones. If the researchers can work out which chalcones these are, and if reliable supplements containing chalcones appear on the market, then athletes might find that they have a new supplement that's worth trying. And it's likely to appeal to athletes who use insulin as a doping agent, we suspect.
Dangerous
Muscles
Heather Kirk-Ballard recently published a study in Nutrition in which Artemisia dracunculus deactivated the gene for microtubule-associated protein-1 light chain 3 [LC3] in the vastus lateralis of diabetic mice. [Nutrition. 2014 Jul-Aug;30(7-8 Suppl):S21-5.] LC3 plays a key role in muscle breakdown.
A year ago Kirk-Ballard published an animal study in PLoS One which showed that mice with diabetes do develop larger muscles when their food contains 1 percent PMI 5011. [PLoS One. 2013;8(2):e57112.]
Going by the number of studies Pennington has produced in recent years on the anticatabolic effect of Artemisia dracunculus, they are taking PMI 5011 seriously. [Nutrition. 2014 Jul-Aug;30(7-8 Suppl):S43-51.] [Nutrition. 2014 Jul-Aug;30(7-8 Suppl):S59-66.] [Diabetes Obes Metab. 2014 Aug;16(8):728-38.] [J Proteomics. 2012 Jun 18;75(11):3199-210.] [Diabetes. 2012 Mar;61(3):597-605.] [J Nutr Biochem. 2011 Jan;22(1):71-8.] [Phytother Res. 2010 Sep;24(9):1278-84.] [Metabolism. 2008 Jul;57(7 Suppl 1):S58-64.]
Speculation
Mechanism
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