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07.04.2019

What is the anabolic effect of 6-keto-progesterone?

In the good old days, men were still real men. Men still did manly things, such as playing Quake and listening to Megadeth. If they were training with weights with a little pharmacological help, they wanted nothing to do with progesterone or progesterone-like substances. Those hormones were for women, not for men who wanted to become more men. This golden time is no longer. Not in the web shops where you buy designer steroids and SARMs, where you nowadays stumble across hundreds of products with 6-keto-progesterone.

First synthesized
6-Keto-progesterone, also known as 6-oxo-progesterone or pregn-4-one-3,6,20-trione, was first synthesized in the late 1930s by German-American chemist Mamilian Ehrenstein (1899-1968). [J. Org. Chem. 1939;4(4):506-18.]

Biological effects
Ehrenstein, who has published several articles about 6-keto-progesterone in the forties and fifties, has few words on the biological effects of 6-keto-progesterone. He does, however, refer to animal studies carried out in his request by other researchers, which show that 6-keto-progesterone has little or no progestational activity at all.

Researchers soon discover that 6-keto-progesterone circulates in the body in small quantities. Its biological effects become clearer in the late 1950s, when Japanese scientists published the article 6-Ketoprogesterone and its biological actions. [Endocrinol Jpn. 1958 Sep;5(3):149-62.]

The Japanese do animal tests, and note that 6-keto-progesterone has no progestagenic effect.

The Japanese study 6-ketoprogesterone with the classical animal tests with which chemists in the twentieth century assess the androgenic and anabolic effect of anabolic steroids. They discover that 6-ketoprogesterone has about as much androgenic and anabolic effect as progesterone.

Click on the figure below for a larger version.

Is 6-keto-progesterone a prohormone?
In theory, 6-keto-progesterone could convert to 6-oxo and 6-hydroxyl androgens. We do not know to what extent these steroids have an anabolic effect. Androgens & Anabolic Agents, the standard work of Julius Vida, does not tell. According to Vida, 6-oxo and 6-hydroxyl androgens have no or little androgenic effect, and their anabolic effect has never been investigated.

Vida relies on an article that - again - Maximilian Ehrenstein published in 1952. [J. Org. Chem. 1952;17(12):1587-96.] In that article, Ehrenstein discusses the results of an animal study with roosters that a friendly researcher carried out for him. Apparently Ehrenstein did not like animal testing.

And that is all we have been able to find about the biological effects of 6-keto-progesterone. It is not much, but more than we have been able to trace about 6-keto-progesterone's safety - which was absolutely nothing.

Caveat emptor.

Source:
Endocrinol Jpn. 1958 Sep;5(3):149-62.

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