If there are only relatively small amounts of inflammatory factors such as TNF-alpha [at right] and CRP circulating in your body, you are less likely to develop cancer and you'll probably age more slowly than if your cells generate large amounts of inflammatory factors. One way to reduce the production of these inflammatory factors is supplementation with Q10, according to a Chinese meta-study.
The researchers traced 9 trials in which patients with metabolic disorders such as overweight, diabetes and non-alcoholic fatty liver were given supplements containing Q10. They gathered all the results and re-analysed them.
Supplementation with Q10 resulted in a statistically significant rise in the amount of Q10 in the blood, and in a statistically significant reduction in the concentration of the inflammatory factor TNF-alpha.
If you click on the figure below, a larger version will pop up.
For the nitpickers among us: the researchers identified three studies that examined TNF-alpha. The doses used in those studies were 100, 300 and 500 mg Q10 per day.
The reduction in concentration of interleukin-6 and C-reactive protein in the blood was not significant.
"The present systematic review provides some evidence that CoQ10 supplementation may partly improve the process of inflammatory state in patients with metabolic diseases," the researchers summarised. "However, the results should be interpreted with caution because of the evidence of heterogeneity."
"Further studies, especially with larger sample size and well-designed randomized controlled trials, are needed to confirm the effectiveness of CoQ10 supplementation on benefitting to inflammation status in metabolic diseases."
Recently geriatricians at Soochow University in China also published a meta-study in which they attempted to gain an overview of the anti-inflammatory effects of Q10. This was not related to people suffering from a disorder or disease. [Pharmacol Res. 2017 Feb 5;119:128-136.] The Soochow study painted a more positive picture than the meta-study done at Sichuan University.
"This meta-analysis of randomized controlled trials suggests significant lowering effects of Q10 on CRP, IL-6 and TNF-alpha," was the conclusion of the Soochow meta-study.
PLoS One. 2017 Jan 26;12(1):e0170172.
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