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Ergo-Log

17.11.2010


Burn 60 kcal a day more with dihydrocapsiate

Capsaicin, a burning component in hot chilli peppers, makes the body use more energy. But the disadvantage is the burning sensation in your stomach, throat and mouth. That's why researchers and manufacturer Ajinomoto are experimenting with non-burning analogues of capsaicin. New results from obesity researchers at Pennington Biomedical Research have recently been published in the American Journal of Clinical Nutrition.

The non-burning capsaicin analogues are an ingredient in Ajinimoto’s CapsiateNature. These analogues are called capsinoids. Japanese researchers discovered them in the late eighties in CH-19 Sweet, an interesting, non-burning variety of the pepper plant.

Overweight test subjects in particular burn more fat when given capsinoids. [Biosci Biotechnol Biochem. 2007 Feb;71(2):380-9.] An American study has shown that test subjects lost 400g in 12 weeks when they took 6 mg capsinoids daily. No, it's not a big weight loss.

The structural formulas of capsinoids and capsaicin are shown below.


Burn 60 kcal a day more with dihydrocapsiate


The Pennington researchers also achieved modest results. They gave seventy overweight subjects a daily dose of 0 [placebo group], 3 or 9 mg dihydrocapsiate, for 28 days. The light dose turned out to be most effective. In this study the 3 mg group burned an extra 60 kcal per day.


Burn 60 kcal a day more with dihydrocapsiate

Burn 60 kcal a day more with dihydrocapsiate


The effect is "in the range of day-to-day resting metabolic rate variability", the researchers write. That's why the subjects that were given the most effective dose of dihydrocapsiate also had an increase in their fat mass of 300g – exactly the same amount as in the placebo group.

The researchers, who were funded by Ajinimoto, are not ready to dismiss dihydrocapsiate yet though. They suggest that the compound might be more effective when combined with exercise. Not such a crazy idea: animal studies have shown that capsinoids boost stamina and total energy expenditure. [J Nutr. 1998 Nov;128(11):1978-83.]

Source:
Am J Clin Nutr. 2010 Nov; 92(5): 1089-93.

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